摘要
骨转移瘤是恶性肿瘤最常见的并发症,其早期检测和诊断对选择最佳治疗方案有重要意义。随着磁共振技术的迅速发展,国内外研究人员相继开展背景信号抑制全身扩散加权成像技术在恶性肿瘤骨转移诊断方面的应用及研究工作。本文综述了WB-DWIBS技术诊断恶性肿瘤骨转移的敏感性、准确性以及与X线、CT、MRI、ECT、PET相比较存在的优势。自2004年报道此项技术,经几年来国内外的研究表明,WB-DWIBS在低信号的背景下,突出了病变的显示,大幅提高了病变组织尤其是骨转移灶的检出率,并且在发现恶性肿瘤早期骨转移方面比PET具有更高的敏感性和准确性,同时还可以显示原发病灶和全身脏器转移灶及淋巴结转移,为临床制定治疗方案提供更多有益信息。WB-DWIBS扫描速度快,无辐射,有逐步取代PET成为全身恶性肿瘤筛查新技术的发展趋势。作为新技术,WB-DWIBS目前还存在一些不足,随着磁共振技术的迅速发展,WB-DWIBS在骨转移瘤的诊断方面将具有广阔的应用价值和推广前景。
Bone metastasis is one of the most common complications of malignant tumors, and early detection and diagnosis have great significance in choosing the best treatment plan. With the rapid development of magnetic resonance, the application and study of whole body diffusion weighted imaging with background suppression （WB-DWIBS） in diagnosing bone metastases from malignant tumors has been performed by researchers both in China and overseas. The sensitivity and accuracy of WB-DWIBS in diagnosing the bone metastases of malignant tumors, and the advantages of the technology compared with x-ray imaging, computed tomogra- phy, magnetic resonance imaging, electrical capacitance tomography, and positron emission tomography are reviewed. Since the technique was first reported by Takahara et al. in 2004, studies over the past few years have indicated that WB-DWIBS under low background signal highlights the manifestation of the lesion, thereby greatly increasing the detection ratio for diseased tissues, especially bone metastases. Moreover, the technique was found to have a higher sensitivity and accuracy for detecting bone metastasis in malignant tumors compared with PET. At the same time, DWIBS can also be used to detect primary lesions and metastases in visceral organs and lymph nodes. Therefore, this technique can provide more useful information for determining the best treatment plan. WB-DWIBS is rapid and emits no radiation. It is a new technology for detecting malignant tumors that has the potential to replace PET. As a new technique, WB-DWIBS still has some limitations. With the rapid development of magnetic resonance, WB-DWIBS will show its unique value in application and the prospect of generalized diagnosis of osseous metastatic tumors.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2011年第11期677-679,共3页
Chinese Journal of Clinical Oncology
关键词
全身扩散加权成像
背景抑制
骨转移瘤
Whole body diffusion weighted imaging
Background suppression
Osseous metastatic tumors
