摘要
目的通过体内外实验探讨润肤消炎洗剂对特应性皮炎(AD)皮损定植金黄色葡萄球菌(金葡菌)的影响。方法选取23例AD患者,左侧(或右侧)上肢(或下肢)的典型皮损作为治疗组靶皮损,对侧相应皮损则作为对照组皮损。(1)治疗组靶皮损以润肤消炎洗剂外洗或湿敷,治疗14 d。对照组皮损不给予治疗。治疗14 d后比较两组皮损处金葡菌定植密度。(2)检测润肤消炎洗剂对标准金葡菌和耐甲氧西林金葡菌(MRSA)的体外抑菌活性。结果 (1)治疗后治疗组靶皮损的金葡菌定植密度[(107 893±260 049)CFU/cm2]显著低于对照组皮损[(343 321±424 940)CFU/cm2],差异有统计学意义(P<0.05)。(2)润肤消炎洗剂(中药浓度1 g/m l)对标准金葡菌和MRSA均具有抑菌作用,与阳性对照组(2%夫西地酸钠)的抑菌作用比较,差异有统计学意义(P<0.01)。结论抗炎、抑制金葡菌可能是润肤消炎洗剂作用的主要机制之一。
Objective To research,by vitro and in vivo experiment,the impact of anti-inflammatory moisturizing lotion on staphylococcus aureus（S.aureus） of atopic dermatitis（AD）.Methods Typical skin lesions of left（or right） upper（or lower） limbs were chosen as targets（treatment group,washed by anti-inflammatory moisturizing lotion,14 days）,contralateral lesions as control group（given no treatment）.After 14 days of treatment,S.aureus field planting density was compared between 2 groups.In vitro antibacterial activity of anti-inflammatory moisturizing lotion on standard S.aureus and methicillin resistant S.aureus（MRSA） was detected.Results S.aureus field planting density was significantly lower in treatment group [（107 893±260 049）CFU/cm2]than in control[（343 321±424 940）CFU/cm2]（P0.05）.Anti-inflammatory moisturizing lotion（concentration：1 g/ml） was of antimicrobial effect on standard S.aureus and MRSA,and there was significant difference between groups treatment and control（2% sodium fusidate）（P0.01）.Conclusion Anti-inflammation and inhibition of S.aureus may be one of the main mechanisms of anti-inflammatory moisturizing lotion.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第18期2062-2065,共4页
Chinese General Practice
基金
广州中医药大学科研创新基金项目(09CX056)
关键词
润肤消炎洗剂
皮炎
特应性
葡萄球菌
金黄色
定植密度
抑菌活性
Anti-inflammatory moisturizing washing formula
Dermatitis
atopic
Staphylococcus aureus
Colonization density
Bacteriostasis
