摘要
目的探讨急性冠状动脉综合征患者外周血基质金属蛋白酶3水平与冠状动脉狭窄严重程度以及基质金属蛋白酶3与心肌酶、肌钙蛋白、血脂等临床指标的关系。方法比较我院77例急性冠状动脉综合征患者与健康对照者外周血基质金属蛋白酶3水平差异,分析急性冠状动脉综合征患者基质金属蛋白酶3水平与冠状动脉狭窄严重程度;以及基质金属蛋白酶3与心肌酶、肌钙蛋白、血脂等的相关性。采用酶联免疫吸附法测定血清基质金属蛋白酶3水平。结果基质金属蛋白酶3水平在急性心肌梗死组与稳定型心绞痛组、健康对照组差异有显著性(P<0.01),在不稳定型心绞痛组与稳定型心绞痛组、健康对照组差异有显著性(P<0.01),在急性心肌梗死组与不稳定型心绞痛组差异无显著性(P>0.05),在稳定型心绞痛组与健康对照组差异无显著性(P>0.05)。基质金属蛋白酶3与肌钙蛋白I、肌酸激酶、肌酸激酶同功酶呈正相关;基质金属蛋白酶3与甘油三酯、低密度脂蛋白胆固醇无相关关系。基质金属蛋白酶3水平与冠状动脉造影狭窄严重程度无相关关系(r=0.293,P=0.053)。经皮冠状动脉介入治疗的急性心肌梗死患者术前及术后基质金属蛋白酶3水平差异有显著性。结论急性冠状动脉综合征患者外周血基质金属蛋白酶3水平增高。血清基质金属蛋白酶3水平与冠状动脉狭窄严重程度无关。急性心肌梗死患者血清基质金属蛋白酶3水平与肌钙蛋白I、肌酸激酶、肌酸激酶同功酶呈正相关。
Aim To investigate the level of matrix metalloproteinase-3 of peripheral blood from acute coronary syndrome patients and to analyize the relationship among matrix metalloproteinase-3, myocardium enzymes, troponins, blood-fat, and severity of coronary artery disease. Methods To contrast matrix metalloproteinase-3 of peripheral blood from 77 acute coronary syndrome patients of our hospital and normal controls, and to analyze relationship among matrix metalloproteinase-3 of peripheral blood, myoeardium enzymes, troponins, blood-fat, and severity of coronary artery disease. Serum level of matrix metalloproteinase-3 was measured by enzyme linked immunosorbent assay. Results Compared with stable angina pectoris group and control group, the level of matrix metalloproteinase-3 in acute myocardial infarction group had statistically significant difference（ P 〈 0. 01 ）. Compared with stable angina pectoris group and control group, statistical significance of difference was seen in unstable angina pectoris group （ P 〈 0. 01 ）. There is no sig- nificant difference between acute myocardial infarction and unstable angina pectoris group, as well as stable angina pectoris and control group. Matrix metalloproeinase-3 and troponin I, creatine kinase, MB isoenzymes of ereatine kinase had pos- itive correlation, There were no correlation between matrix metatloproteinase-3, triglyeride, low density lipoprotein cholesterol. Matrix metalloproteinase-3 level and coronary artery radiography pathological change severity were performed by Pc-arson correlation ： there were no correlation （ r = 0. 293 ; P = 0. 053 ）. There were significant difference of matrix metal- toproteinase-3 in 10 patients with acute myocardial infarction before and after percutem coronary artery interventional thera- py （ P 〈 0. 01 ）. Conclusion The level of matrix metalloproteinase-3 of peripheral blood in patients with acute coro- nary syndrome was increased. The level of matrix metalloproteinase-3 and coronary artery radiography severity had no correlation. Matrix metalloproteinase-3 and troponin I, creatine kinase, MB isoenzymes of creatine kinase had positive correlation in patients with acute myocardial infarction.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2011年第5期435-438,共4页
Chinese Journal of Arteriosclerosis
