摘要
目的探讨仙灵脾对2型糖尿病(T2DM)大鼠肾脏的保护作用及作用机制。方法高脂高糖饲料加小剂量链脲佐菌素建立T2DM大鼠模型。将大鼠随机分为正常对照组(n=10)、模型组(n=16)、仙灵脾组(n=16)和二甲双胍组(n=12);8周处死大鼠,取血、尿、肾标本,检测血糖、肾功能、肾脏指数、TG、TC及24 h尿蛋白水平。结果与模型组比较,仙灵脾组的肾脏指数和24 h尿蛋白水平均明显降低(P均<0.05)。结论仙灵脾可能对糖尿病大鼠的肾脏有保护作用。
Objective It is to explore the protecting effect of epimedium on urine protein and its mechanism in type 2 diabetes mellitus（T2DM） rats.Methods T2DM models of rats were induced by small dosage of Streptozotocin（STZ） and high fat and sugar diet.The rats were divided into normal control group（n=10）,model group（n=16）,epimedium group（n=16） and metformin group（n=12）.After 8 weeks the rats were killed and specimens of their blood,urine and kidney were gotten to determine FBG,TC,TG,KHI and 24 h UAlb.Results Compared with the model group,FPG,KHI and 24 h UAlb of the epimedium group were significantly decreased（P0.05）.Conclusion Epimedium may has some protective effect on kidney of diabetic rats.
出处
《现代中西医结合杂志》
CAS
2011年第19期2358-2359,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
仙灵脾
糖尿病肾病
2型糖尿病
epimedium
diabetic nephropathy
type 2 diabetes
