摘要
目的探讨早期应用生长抑素（somatostatin，ss）联合中药方剂柴芩承气汤对重症急性胰腺炎（severe acute pancreatitis，SAP）的治疗效果。方法将符合SAP诊断标准的38例患者随机分成两组，其中治疗组21例，在早期应用生长抑素泵入同时胃管内注入柴芩承气汤治疗；对照组17例只接受生长抑素和其他常规对症等治疗。观察两组患者腹部体征消失的时间、血淀粉酶恢复情况、血糖、肝肾功能恢复情况、住院天数及死亡率。结果治疗组腹痛、腹胀症状消失时间快于对照组，差异有统计学意义（P〈0．05）；两组血淀粉酶、血糖恢复正常时间及病死率比较，差异无统计学意义（P〉0．05）；与对照组相比，治疗组谷丙转氨酶（ALT）、谷草转氨酶（AST）、碱性磷酸酶（ALP）、谷氨酸脱氢酶（LDH）及血脂（Lipase）等指标恢复速度更快，住院天数明显缩短，差异有统计学意义（P〈0．05）。结论早期应用生长抑素联合柴芩承气汤胃管内注入中西医结合治疗SAP，可更快改善患者腹痛、腹胀症状，改善患者肝肾功能，减少患者住院天数，但对血淀粉酶、血糖恢复时间无明显影响。
Objective To observe the therapeutic effect of Chai Qin Cheng Qi decoction by nasogastric feeding combined with somatostatin on severe acute pancreatitis （SAP）. Methods Thirty - eight patients with SAP were randomly divided into two groups： the control group （n = 17） was treated with conventional therapy （ intensive care, fasting, gastrointestinal decompression, somatostatin, antibiotics）, the treatment group （n = 21 ） was treated with Chai Qin Cheng Qi decoction by nasogastric feeding combined with somatostatin. The extinction time of abdominal pain and abdominal distension, serum biochemical criteria （amylase, blood glucose, ALT, AST, ALP, LDH, lipase, Cr）, mortality and the days in hospital were observed and compared. Results The extinction time of abdominal pain and abdominal distension were all shorter in treatment group than in control group （ P 〈 0. 05 ）, ALT, AST, ALP, LDH as well as lipase in the treatment group recovered more quickly than those in the control group, and the days in hospital obviously reduced. There was no statistical difference in the reviving tittle of blood amylase and blood glucose between the two groups （P 〉 O. 05） , and the mortality had no significant differences between two groups. Conclusion Chai Qin Cheng Qi decoction by nasogastric feeding combined with somatostatin can quickly improve the syndromes of abdominal pain and abdominal distension, the function of liver and renal, and reduce obviously the admission days, but has no effect on the reviving time of blood amylase and blood glucose.
出处
《中国急救医学》
CAS
CSCD
北大核心
2011年第6期537-540,共4页
Chinese Journal of Critical Care Medicine
关键词
重症急性胰腺炎(SAP)
生长抑素(SS)
柴芩承气汤
中西医结合治疗
Severe acute pancreatitis （SAP）
Somatostatin
Chai Qin Cheng Qi decoction
Integrated traditional chinese medicine and western medicine
