摘要
目的:探讨左旋甲状腺素替代治疗先天性甲状腺功能减低症患儿的疗效。方法:将确诊的80例甲低患儿,按不同左旋甲状腺素起始剂量分成3组进行治疗,并观察疗效。结果:治疗后第1个月TSH比较,第1组>第2组>第3组(P<0.05),第3组患儿TSH恢复正常,但第1和第2组TSH仍高于正常。各组血清FT3和FT4比较,无显著性差异(P>0.05),均达到正常指标。4岁时患儿进行智商测定,各组VIQ、PIQ及FIQ有显著性差异,第3组>第2组>第1组(P<0.05)。3组患儿之间身高无显著性差异。结论:尽早用较大剂量的左旋甲状腺素使得TSH迅速恢复正常,能保证患儿正常智力和体格发育。
Objective：To observe the clinic effect in the treatment of earlier levothyroxine replacement in children with congenital hypothyroidism.Methods：80 patients who were confirmed as congenital hypothyroidism,according to different initial dose of levothyroxine treatment were divided into three groups.The patients came back to the hospital for a return visit examination in four years respectively.Results：After a month＇s treatment,the mean TSH in each group had significant differences,the first groupsecond groupthird group（P0.05）.Nevertheless,there were no significant difference in FT3 and FT4（P0.05）.There were remarkable significances in the mean verbal IQ（VIQ）,performance IQ（PIQ）and total scores after 4 years,and the third groupsecond groupfirst group（P0.05）.There were no significant difference in height.Conclusion：The early treatment with a larger dose of levothyroxine are necessary in improving the normal mental and physical development in children with congenital hypothyroidism.
出处
《医学理论与实践》
2011年第12期1376-1377,1386,共3页
The Journal of Medical Theory and Practice
基金
广东省惠州市科技局(编号:2008Y063)
