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PCI术后再狭窄患者的survivin水平及红花黄色素的干预作用 被引量:3

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摘要 目的探讨经皮冠状动脉介入治疗(PCI)术后再狭窄患者的血浆中凋亡抑制因子survivin水平变化及应用红花黄色素的干预效果。方法 60例PCI术后6个月内复查冠状动脉造影的患者,按照冠状动脉造影结果分为再狭窄组(28例)、无再狭窄组(32例),并以同期冠状动脉造影完全正常者作为对照组(30例)。20例择期行PCI术的患者随机分为用药组和未用药组,用药组术后当天即予红花黄色素40 mg/d,连用7 d,两组其余治疗方案相同。采用酶联免疫吸附试验检测血浆survivin水平。结果再狭窄组的血浆survivin水平显著高于对照组和无再狭窄组(均P<0.01),无再狭窄组的血浆survivin又显著高于对照组(P<0.01)。PCI术后患者血浆survivin水平于术后6 h即急剧增高,未用药组在术后3 d达最高峰,术后7 d仍处于高水平;用药组于术后24 h达最高峰;两组术后各时间点的血浆survivin水平均显著高于术前(均P<0.01)。用药组术后3、7 d的血浆survivin水平均显著低于未用药组(均P<0.01)。结论 PCI术后血浆survivin持续增高与PCI术后再狭窄有关,而红花黄色素可降低PCI术后血浆survivin的升高幅度,减少再狭窄事件。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第11期1991-1993,共3页 Chinese Journal of Gerontology
基金 吉林省教育厅十一五重大课题(No.2010123)
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参考文献7

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