摘要
通过探究吡唑酸的四种不同合成方法,筛选了适合于工业化生产的合成路线;并利用农药氯虫酰胺重要中间体——3-溴-1-(3-氯吡啶-2-基)-1H-吡唑-5-甲酸的合成进行了验证,产物结构经核磁共振谱(1H NMR)确认.
The best route to the industrialized synthesis of pyrazole acids was screened by exploring four kinds of different synthetic methods of pyrazole acids.The route was verified by successful synthesis of 3-bromo-1-（3-chloro-2-pyridinyl）-1H-pyrazole-5-carboxylic acid,an important intermediate of pesticide chlorantraniliprole.The structure of the product was confirmed by means of nuclear magnetic resonance spectroscopy（1H NMR）.
出处
《化学研究》
CAS
2011年第3期40-43,共4页
Chemical Research
关键词
吡唑酸
农药
中间体
工业化
合成
pyrazole acid
pesticide
intermediate
industrialization
synthesis
