摘要
采用电化学发光技术对166例妊娠期肝内胆汁淤积症（ICP）患者血清促甲状腺激素（TSH）、游离甲状腺素（FT4）、甲状腺过氧化物酶抗体（TPOAb）水平进行检测,并与正常妊娠妇女及参与筛查的妊娠妇女进行比较.结果 显示,与正常妊娠妇女比较,ICP孕妇血清TSH、TPOAb明显升高,FT4水平无明显变化,其TPOAb阳性率达22.9%（38/166）.ICP孕妇易合并各种甲状腺疾病,总发生率35.5%（59/166）,明显高于同期筛查妊娠妇女17.1%（143/837）.妊娠期ICP妇女甲状腺功能存在异常,可能参与了ICP的发生及发展.
A total of 166 women with intrahepatic cholestasis in pregnancy （ICP） participated in the study. Serum levels of thyroid stimulating hormone （TSH）, free thyroxine 4 （FT4） and thyroid peroxidase antibody （TPOAb） were quantified for all of them with electrochemiluminescence （ECL） technique, and compared with those in normal pregnant women. Results showed that serum TSH and TPOAb [22. 9%（38/166）] increased significantly, but no significant change in serum level of FT4 was observed in women with ICP, as compared to those in normal pregnant women. Overall prevalence of thyroid diseases in ICP women was 35.5% （59/166）, significantly higher than that in normal population screened for thyroid disease （17. 1%, 143/837） at the same time period. It suggests that thyroid dysfunction may be involved in pathogenesis of ICP.
出处
《中华全科医师杂志》
2011年第6期417-419,共3页
Chinese Journal of General Practitioners
基金
江苏省常州市卫生局资助项目（W2200821）
