期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

线粒体损伤与糖尿病肾病 被引量：14

原文传递
导出
摘要 研究证实线粒体损伤在糖尿病及其并发症的发病机制中起着关键作用。线粒体是真核细胞生存和发挥功能的重要细胞器，它通过氧化磷酸化途径产生机体内大部分ATP，在形态上通过不断的分裂和融合，
作者 詹明 董政 孙林
机构地区 中南大学肾脏病研究所湖南省血液净化与肾脏病重点实验室湘雅二医院肾内科 美国乔治亚州医学院细胞生物学与解剖系
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2011年第6期460-463,共4页 Chinese Journal of Nephrology
基金 国家自然科学基金（30971379）
关键词 线粒体损伤 糖尿病肾病 氧化磷酸化 发病机制 细胞生存 并发症 细胞器 ATP
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献35

  • 1Brownlee M.Biochemistry and molecular cell biology of diabetic complications.Nature,2001,414:813-820.
  • 2Lowell BB,Shulman GI.Mitochondrial dysfunction and type 2 diabetes.Science,2005,307:384-387.
  • 3Westermann B.Mitochondrial fusion and fission in cell life and death.Nat Rev Mol Cell Biol,2010,11:872-884.
  • 4Cho DH,Nakamum T,Fang J,et al.S-nitrosylation of Drpl mediates beta-amyloid-related mitochondrial fission and neuronal injury.Science,2009,324:102-105.
  • 5Okamoto K,Shaw JM.Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes.Annu Rev Genet,2005,39:503-536.
  • 6Wang W,Fang H,Groom L,et al.Superoxide flashes in single mitochondria.Cell,2008,134:279-290.
  • 7Danial NN,Korsmeyer SJ.Cell death:critical control points.Cell,2004,116:205-219.
  • 8Suen DF,Norris KL,Youte RJ.Mitochondrial dynamics and apoptosis.Genes Dev,2008,22:1577-1590.
  • 9Giorglo M,Migliaccio E,Orsini F,et al.Electron transfer between cytochrome C and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis.Cell,2005,122:221-233.
  • 10Green DR,Kroemer G.The pathophysiology of mitochondrial cell death.Science,2004,305:626-629.

二级参考文献29

  • 1Satchell SC,Tooke JE.What is the mechanism of microalbuminuria in diabetes:a role for the glomerular endothelium? Diabetologia,2008,51:714-725.
  • 2Kanwar YS,Akagi S,Sun L,et al.Cell biology of diabetic kidney disease.Nephron Exp Nephrol,2005,101:e100-e110.
  • 3Kanwar YS,Wada J,Sun L,et al.Diabetic nephropathy:mechanisms of renal disease progression.Exp Biol Med (Maywood),2008,233:4-11.
  • 4Hjalmarsson C,Johansson BR,Haraldsson B.Electron microscopic evaluation of the endothelial surface layer of glomerular capillaries.Microvasc Res,2004,67:9-17.
  • 5Nieuwdorp M,Mooij HL,Kroon J,et al.Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes.Diabetes,2006,55:1127-1132.
  • 6Jeansson M,Haraldsson B.Glomerular size and charge selectivity in the mouse after exposure to glucosaminoglycandegrading enzymes.J Am Soc Nephrol,2003,14:1756-1765.
  • 7Satchell SC,Tasman CH,Singh A,et al.Conditionally immortalized human glomerular endothelial cells expressing fenestrations in response to VEGF.Kidney Int,2006,69:1633-1640.
  • 8De Vriese AS,Tilton RG,Elger M,et al.Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes.J Am Soc Nephrol,2001,12:993-1000.
  • 9Segev Y,Eshet R,Yakir O,et al.Systemic and renal growth hormone-IGF1 axis involvement in a mouse model of type 2 diabetes.Diabetologia,2007,50:1327-1334.
  • 10Segev Y,Eshet R,Rivkis I,et al.Comparison between somatostatin analogues and ACE inhibitor in the NOD mouse model of diabetic kidney disease.Nephrol Dial Transplant,2004,19:3021-3028.

共引文献14

同被引文献255

引证文献14

二级引证文献186

中华肾脏病杂志
2011年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部