摘要
目的设计合成一系列新型喹啉双芳基脲类化合物作为潜在的蛋白酪氨酸激酶抑制剂。方法以2甲-基-2苯基丙酸为原料经过9步反应,合成了12个喹啉衍生物,结构经过1H-NMR鉴定。结果合成的12个目标化合物,均未见文献报道。结论该合成方法简单易行,可作为一系列喹啉类蛋白酪氨酸激酶抑制剂的合成通法。
Objective To synthesize novel quinoline derivatives as antitumor drug candidates.Methods 12 derivatives of quinoline were synthesized in nine steps from 2-methyl-2-phenylpropanoic acid.Their structures were identified by 1H-NMR.Results Twelve novel compounds were synthesized.Conclusion This method can be a general method to synthesize a series of novel quinoline derivatives as protein tyrosine kinase inhibitors.
出处
《解放军药学学报》
CAS
2011年第3期189-192,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
肿瘤
蛋白酪氨酸激酶
蛋白酪氨酸激酶抑制剂
喹啉衍生物
合成
cancer
protein tyrosine kinase
protein tyrosine kinase inhibitors
quinoline derivatives
synthesis
