摘要
目的探讨帕瑞昔布钠用于腹部小手术后镇痛的有效性及安全性。方法择期硬膜外腔阻滞下行腹股沟疝修补、阑尾切除手术患者240例,随机等分为3组:实验组帕瑞昔布钠20 mg组(PL组)、帕瑞昔布钠40 mg组(PH组)及对照组(N组),每组80例。实验组于缝皮时静脉注入帕瑞昔布钠20 mg、40 mg;12 h后重复给予;对照组给予同等剂量生理盐水。采用视觉模拟量表(visual analogue scale,VAS)对术后2、4、8、12、18、24 h进行疼痛评分,同时观察术后各种不良反应及对凝血功能的影响。结果 PL组和PH组在术后各时点的VAS评分均明显低于N组,对疼痛治疗满意度明显高于N组(P<0.05);而PH组在术后12和24 h,2个时间点VAS评分明显低于PL组,对疼痛治疗满意度明显高于PL组(P<0.05)。结论帕瑞昔布钠用于成年患者腹部小手术后每日两次可起到明显的镇痛效果、不良反应少,而且帕瑞昔布钠40 mg较20 mg更有效。
Objective To investigate the efficacy and safety of parecoxib sodium for postoperative analgesia in minor abdomen sugery. Methods 240 patients scheduled for inguinal hernia repair or appendectomy under spinal anesthesia were randomly divided into 3 groups （n = 80 each） and received a single injection of 20,40 mg parecoxib sodium （study group PL, PH ） or placebo （control group N） immediately and 12 h after the operation. The intensity of pain was measured using VAS scores and recorded at 2, 4, 8, 12, 18 and 24 h after operation. The adverse effects and the results of clinical laboratory tests were observed. Results The VAS scored at different time points was significantly lower in the two study groups than in the control group （ P 〈 0. 05 ）. Far more patients in the two study groups rated their pain management as good or excellent（ P 〈 0. 05 ）. Compared with group PL, the VAS scores in group PH at 12 h and 24 h were lower and the level of satisfaction was significantly higher （ P 〈 0.05 ）. Conclusion Parecoxib sodium 20 mg or 40 mg given intravenously twice a day has analgesic effect and less side effects on adult patients after minor abdomen surgery. In addition, parecoxib sodium 40 mg is a better pain relief than Dareeoxib sodium 20 mg.
出处
《武警医学》
CAS
2011年第6期479-481,共3页
Medical Journal of the Chinese People's Armed Police Force
关键词
帕瑞昔布钠
腹部小手术
镇痛
parecoxib sodium
minor abdomen sugery
analgesia
