摘要
在稀盐酸介质中,阿昔洛韦能还原Fe3+为Fe2+,Fe2+进一步与[Fe(CN)6]3-反应生成配合物Fe3[Fe(CN)6]2,此时能引起RRS光谱的显著增强。散射强度(ΔI)在一定范围内与药物浓度呈线性关系,方法对阿昔洛韦的检出限为0.038μg/mL,线性范围0.05～4.0μg/mL。文章研究了RRS法的适宜反应条件和共存物质的影响,由此发展了高灵敏、简便快速测定阿昔洛韦的新方法,可用于尿样中阿昔洛韦的测定。
In dilute HCl solution medium,Fe3＋ could be reduced to Fe2＋ by acyclovir and Fe2＋ could further react with [Fe（CN）6]3-to form Fe3[Fe（CN）6]2,which led to the significant enhancement of RRS spectrum.RRS intensity was proportional to the concentration of acyclovir in the rang of 0.05～4.0 μg/mL,the detection limit（3 σ） was 0.038 μg/mL.The method had high sensitivity and good selectivity,which was applied to the determination of acyclovir in uric samples with satisfactory results.
出处
《广东化工》
CAS
2011年第6期222-223,共2页
Guangdong Chemical Industry
关键词
阿昔洛韦
共振光散射法
振瑞利散射光谱
acyclovir
Resonance Rayleigh Scattering（RRS）
Resonance Rayleigh Scattering Spectra
