摘要
目的:通过对598例复治涂阳痰培养和药敏结果分析,了解复治涂阳患者的分枝杆菌的菌种分布及复治患者耐药情况,指导临床医生合理选择抗结核药物和治疗方案。方法:对598例复治涂阳痰培养和药敏数据进行分析。结果:598例复治涂阳痰共分离结核分枝杆菌535株,非结核分枝杆菌29株。结核分枝杆菌复合群对6种抗结核药物的耐药率:链霉素26.9%、异烟肼35%、利福平30.7%、乙胺丁醇15.5%、氧氟沙星12.9%、卡那霉素1.5%;MDR耐药率为23.2%;XDR耐药率为1.1%。结论:复治涂阳患者的耐药率比较高,需根据药敏结果合理选择治疗方案。部分复治涂阳患者为NTM病,应引起临床医生的重视。
Objective：To understand the drug resistance and distribution of mycobacteria in retreated patients with smear positive,and provide reasonable regimens to doctors.. Method：From October 2008 to November 2010, 598 sputa from retreated patients with smear positive were collected and cultured. The clinical isolates were identified,and the drug resistance was analyzed by drug susceptibility test. Result ：A total of 564 strains of mycobacteria were isolated,among which 535 strains were Mycohacterium tuberculosis complex,29 strains were non-tubercular mycobacteria. The resistance rate of drug susceptibility test of streptomycin, isoniazid, rifampicin, ethamhutol, ofloxacin and kanamyein were 26.9%, 35%, 30.7%, 15.5%,12.9%, 1.5%, respectively.. The MDR-TB resistance rate was 23.2 % ;the XDR-TB resistance rate was 1.1 %. Conclusion： The resistance rate was higher among retreated patients, treatment regimen should be changed according to the result of drug susceptibility test. Some of retreated patients were infected by NTM.
出处
《临床血液学杂志（输血与检验）》
CAS
2011年第3期336-337,共2页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
关键词
分枝杆菌
耐药性
细菌
mycobacteria
drug resistance
bacterial
