期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

性别与自身免疫性疾病 被引量：8

Sex and Autoimmune Disease
原文传递
导出
摘要 自身免疫性疾病在人群中感染率5-10%,具有明显的性别差异,女性患者显著高于男性,具体机制仍未研究清楚。研究发现,除了机体自身的遗传易感体质外,雌激素,微嵌合体和性染色体都与自身免疫性疾病发病有关。 Autoimmune diseases are estimated to affect 5-10% of the population with a significant female predominance reported for most of them. The mechanism of this sex bias remains unclear. Including a susceptible genetic background, autoimmune diseases are expected to be associated with estrogen, microchimerism and sex chromosome.
作者 颜冬菁 黄欣媛 冷明垒 陈正望 陆婕
机构地区 华中科技大学生命科学与技术学院分子生物物理教育部重点实验室
出处 《现代生物医学进展》 CAS 2011年第13期2562-2564,共3页 Progress in Modern Biomedicine
基金 湖北省自然科学基金(2009CDB076) 中央高校基本科研业务费资助 HUST:(2010MS009)
关键词 自身免疫性疾病 性别差异 雌激素 微嵌合体 性染色体 Autoimmune diseases Sex bias Estrogen Microchimerism Sex chromosome
分类号 R593.2 [医药卫生—内科学]
  • 相关文献

参考文献8

  • 1Siracusa MC, Overstreet MG, Housseau F, et al. 17beta-estradiol alters the activity of conventional and IFN-producing killer dendritic ceils [J]. J Immunol, 2008, 180(3): 1423-1431.
  • 2Carrel L, Willard HF. X-inactivation profile reveals extensive variability in X-linked gene expression in females [J]. Nature, 2005, 434 (7031): 400-404.
  • 3Chagnon P, Provost S, Belisle C, et al. Age-associated skewing of X-inactivation ratios of blood cells in normal females: a candidate-gene analysis approach [J]. Exp Hematol, 2005, 33(10): 1209-1214.
  • 4Miozzo M, Selmi C, Gentilin B, et al. Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis [J]. Hepatology, 2007, 46(2): 456-462.
  • 5Noguchi M, Yi H, Rosenblatt HM, et al. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immun- odefieiency in humans [J]. Cell, 1993, 73(1): 147-157.
  • 6Stevens AM, Hermes HM, Rutledge JC, et al. Myocardial-tissue- specific phenotype of maternal microchimerism in neonatal lupus congenital heart block [J]. Lancet, 2003, 362(9396): 1617-1623.
  • 7Kenichi Nomura,Yoshio Sumida,Takaharu Yoh,Atsuhiro Morita,Yosuke Matsumoto,SawakoTaji,NaohisaYoshida,MasahitoMinami,YoshitoItoh,ShigeoHoriike,Keisho Kataoka,Masafumi Taniwaki,Takeshi Okanoue.Lack of evidence for leukocyte maternal microchimerism in primary biliary cirrhosis[J].World Journal of Gastroenterology,2004,10(16):2415-2416. 被引量：2
  • 8马铮(综述,王如文(审校).Foxp3基因与自身免疫性疾病[J].免疫学杂志,2008,24(1):111-113. 被引量：13

二级参考文献40

  • 1Lo YM,Patel P, Sampietro M,Gillmer MD,Fleming KA,Wainscoat JS.Detection of single-copy fetal DNA sequence from maternal blood .Lancet 1990:335:1463-1464.
  • 2Thomas MR,Williamson R, Craft I,Yazdani N,Rodeck CH.Y chromosome sequence DNA amplified from peripheral blood of women in early pregnancy. Lancet 1994:343:413-414.
  • 3Bianchi DW. Prenatal diagnosis by analysis of fetal cells in maternal blood.J Pediatr 1995:127:847-856.
  • 4Nelson JL, Maternal-fetal immunology and autoimmune disease:is some autoimmune disease auto-alloimmune or alloautoimmune? Arthritis Rheum 1996:39:191-194.
  • 5Artlett CM,Smith JB, Jimenez SA.Idetification of fetal DNA and cells in skin lesions from women with systemic sclerosis.N Engl J Med 1998:338:1186-1191.
  • 6Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, Smith A, Bean MA, Ober C,Bianchi DW. Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet 1998:351:559-562.
  • 7McDonnell WM. Is primary biliary cirrhosis a complication of pregnancy? Hepatology 1998:28:593-594.
  • 8Tanaka A, Lindor K, Gish R, Newsome M, Gershwin ME. Fetal microchimerism alone does not contribute to the induction of primary biliary cirrhosis. Hepatology 1999:30:833-838.
  • 9Rubbia-Brandt L, Philippeaux MM. Chavez S, Mentha G,Borisch B, Hadengue A. FISH for Y chromosome in women with primary biliary cirrhosis:lack of evidence for leukocyte microchimerism. Hepatology 1999:30:821-822.
  • 10Invernizzi P, De Andreis C, Sirchia SM, Battezzati PM. Zuin M. Rossella F, Perego F, Bignotto M, simoni G, Podda M. Blood fetal microchimerism in primary biliary cirrhosis. Clin Exp Immunol 2000:122:418-422.

共引文献13

同被引文献70

引证文献8

二级引证文献37

现代生物医学进展
2011年 第13期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部