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犬年轻恒牙血管再生法动物模型建立的影响因素 被引量：2

The effect factors of animal modeling of pulpal revascularization in immature dog permanent teeth
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摘要 目的:探讨犬年轻恒牙血管再生法动物模型建立的影响因素。方法:杂种犬3只,选取牙根未发育完成的上颌恒前牙及下颌恒前磨牙共36个牙根为样本,建立根尖周炎模型后构建血管再生法动物模型。结果:3个牙根未形成血凝块,4个牙根MTA充填不佳,7个牙根出现了牙周炎,5个牙根冠折,1个牙根脱落。结论:血凝块的质量,矿化三氧化聚合体(MTA)的充填技术,牙周炎的出现,疼痛等因素对模型的建立有一定的影响。 Objective：To investigate the expression of Id1 in salivary adenoid cystic carcinoma,and examine its cor-relation with patients＇clinicopathological characteristics and tumor angiogenesis.Method：Immunohistochemical（Envi-sionTM）technique was used to examine the expression of Id1 in 46 adenoid cystic carcinoma cases and 10 normal salivary glands cases.SPSS 16.0 software package was employed to analyze experimental data statistically.Result：The expression of Id1 in salivary adenoid cystic carcinoma was 65.2 %,significantly higher than that in normal salivary glands tissues（P 0.01）.The expression of Id1 significantly correlated with tumor pathologic classification,tumor TNM grading and tumor metastasis（P 0.05）,but not with age and gender（P 0.05）.The expression of Id1 significantly correlated with tumor mi-crovessel density marked by CD34（P 0.05）.Conclusion：Id1 expression significantly correlates with the clinicopathological characteristics of salivary adenoid cystic carcinoma.It may correlate with tumor progression and metastasis by promoting tu-mor angiogenesis.[Key words] Immunohistochemistry;Id1;CD34;Tumor angiogenesis;Adenoid cystic carcinoma
作者 文春媚 黄杨 陈文霞 张映娟 钟小奕 李康婧
机构地区 广西医科大学附属口腔医院牙体牙髓病科
出处 《临床口腔医学杂志》 2011年第6期340-342,共3页 Journal of Clinical Stomatology
基金 2010年广西科学研究与技术开发计划项目(桂科攻10124001A-42) 2010年广西研究生教育创新计划项目(2010105981003M221) 广西医疗卫生重点科研课题(桂卫重200637)
关键词 年轻恒牙 血管再生 动物模型 immature permanent teeth revascularization animal model
分类号 R780.2 [医药卫生—口腔医学]
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参考文献15

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同被引文献26

  • 1王青,林秀娟,林志勇,刘桂香,单秀莉.血管内皮生长因子在人年轻恒牙及成熟恒牙牙髓中的表达[J].上海口腔医学,2007,16(3):285-289. 被引量：9
  • 2Iwaya S I,Ikawa M,Kubota M. Revascularization of an imma- ture permanent tooth with apical periodontitis and sinus tract [J]. Dent Traumato1,2001,17(4) : 185-187.
  • 3Wang X,Thibodeau B,Trope M,etal. Histologic characteriza- tion of regenerated tissues in canal space after the revitaliza- tion/revascularization procedure of immature dog teeth with apical periodontitis[J]. J Endod ,2010,36(1) : 56-63.
  • 4Belobrov I,Parashos P. Treatment of tooth discoloration after the use of white mineral trioxide aggregate[J]. J Endod, 2011,37(7) 1017-1020.
  • 5Huang G T. A paradigm shift in endodontic management of immature teeth: conservation of stem cells for regeneration [J]. JDent,2008,36(6): 379-386.
  • 6Thibodeau B, Trope M. Pulp revascularization of a necrotic infected immature permanent tooth: case report and review of the literature[J]. Pediatr Dent ,2007,29(1) : 41-50.
  • 7S Huumonen D. Radiological aspects of apical periodontitis[J]. Endodontic Topics, 2002,1 (1) 3-25.
  • 8Kettering J D,Torabinejad M. Investigation of mutagenicity of mineral trioxide aggregate and other commonly used root- end filling materials[J]. J Endod, 1995,21(11) :537-542.
  • 9Saad A Y. Calcium hydroxide and apexogenesis[J]. Oral Surg Oral Med Oral Patho1,1988,66(4) :499-501.
  • 10Petrino J A, Boda K K, Shambarger S,et al. Challenges in re- generative endodontics a case series [J]. J Endod, 2010, 36(3) 536-541.

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临床口腔医学杂志
2011年 第6期

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