摘要
目的探讨自体外周血干细胞对肝硬化患者肝纤维化的治疗作用。方法选择肝硬化失代偿期患者35例,在内科综合治疗的基础上予自体外周血干细胞治疗作为A组,常规治疗20例作为B组(对照组)。A组经肝动脉将细胞悬液移植入肝脏,分别在治疗前与治疗后第8周、第24周检测肝硬化患者的肝纤维化指标。结果 A组在治疗后第8周,肝纤维化指标较治疗前好转,但改善不明显,第24周肝纤维化指标明显改善,与对照组比较有显著性差异。肝脏B超示治疗前肝脏缩小,呈结节状。治疗后24周可见肝脏增大,实质回声增强增粗。结论自体外周血干细胞可以改善肝硬化患者的肝纤维化。
Objective To explore the effect of autologous peripheral blood stem cell in the treatment of liver fibrosis. Methods 55 cases of cirrhosis patients with decompensated function were randomly divided into an autologous peripheral blood stem cell group （ group A, 35 cases） , and a control group （ group B, 20 cases）. After isolation and purification, the stem cells were transplanted into the liver via hepatic artery. After transplantation, liver fibrosis data were recorded at the 8th and 24th week respectively. Results After transplantation, levels of liver fibrosis indicators were decreased. The difference was significant at the 24th week （ P 〈 0.01 ）. Type-B ultrasonic test saw significant improvement in hepatic fibrosis in group A as compared with group B （ P 〈 0. 05 ）. No significant difference was found in hepatic fibrosis after group B was treated. Conclusion The method of autologous peripheral blood stem cell transplantation was effective for the treatment of liver fibrosis.
出处
《淮海医药》
CAS
2011年第4期307-309,共3页
Journal of Huaihai Medicine
关键词
肝硬化
移植
自体
外周血干细胞移植
Liver cirrhosis
Transplantation, autologous
Peripheral blood stem cell transplantation
