摘要
中介体复合物(Mediator Complex)是由多个在进化上高度保守的蛋白质组成的复合物,它是RNA聚合酶Ⅱ转录装置中的一个重要辅助因子,是介于转录因子与RNA聚合酶Ⅱ之间传递信息的桥梁。在哺乳动物细胞中,不同信号转导通路通过激发其特异控制的转录因子与中介体复合物中特定的组分蛋白发生相互作用,从而调控下游基因的表达。此外,中介体复合物还可以与各种辅因子相互作用,而这些相互作用最终使得中介体复合物可以整合接收到的各种信息并输出为下游基因的激活或沉默,进而控制细胞的增殖、分化及各种生理功能。该文将结合近年来的研究成果,对中介体复合物在真核转录中的调控机制及其生物学功能作一简要综述。
Mediator Complex is an evolutlonarlly conserveu, muiuprotein complex.As an essential part of the Pol II transcriptional machinery, Mediator Complex functions as a molecular bridge to transduce regulatory information from DNA-binding transcription factors to Pol II. In metazoan cells, different transcription factors, in response to respective signaling pathways, physically interact with different Mediator subunits to control expression of the specific set of genes. In addition, Mediator Complex could interact with many cofactors involved in tran- scriptional and epigenetic regulation. These multiple and dynamic interactions allow Mediator Complex to control cell growth, proliferation, differentiation, and diverse biological processes by intergrating signaling and delivering outputs to downstream genes. This review mainly focuses on the recent progress in understanding the mechnisms of Mediator Complex in regulating eukaryotic transcription.
出处
《中国细胞生物学学报》
CAS
CSCD
2011年第6期597-607,共11页
Chinese Journal of Cell Biology
基金
科技部973计划(No.2009CB941100)
国家自然科学基金(No.30770452
No.81030047)
上海市科委(No.08DJ1400500)资助项目~~
