摘要
AECⅡ是肺泡壁的重要组成部分,也是ALI/ARDS发生、发展的重要参与者。AECⅡ可通过分泌炎症介质和促凝、抗凝因子参与ALI时全身炎症反应综合征和凝血反应失衡的形成。AECⅡ上Na+-K+-ATP酶活性以及数量的下调加重了ALI时的肺水肿。肺组织内的AECⅡ增生并转化为AECⅠ以及间质细胞参与了肺损伤后的修复和纤维化的形成。而且,AECⅡ还具有免疫调节功能,参与肺组织内的防御反应。近年来研究发现,与AECⅡ相关的生物标志物SP-D和KL-6与ALI/ARDS肺损伤的严重程度及疾病的预后相关,但尚无对SP-D或KL-6与炎症反应相关性的研究。
Alveolar epithelial cells type Ⅱ is one of the most important component of alveolar wall, and also important participant during the origination and development of ALI/ARDS.AEC Ⅱ can secrete inflammatory factors, procoagulant and anti-coagulant factors to participate in the formation of SIRS and the imbalance of coagulation.The down-regulation of the activity and number of Na＋- K＋-ATPase expressed in AEC aggravates pulmonary edema during ALI.And AEC Ⅱ proliferate and transform into AEC2 I and interstitial cells, contribute to the repair after lung injury and fibrosis.Also AEC Ⅱ possess immunoregulation functions.Recent years, researchers have found that surfactant protein D （ SP-D ） and KL-6 are related to the severity and outcomes of ALI/ARDS.But nowadays there is no research about the relationship between SP-D/KL-6 and inflammatory reaction.
出处
《中国医药科学》
2011年第11期23-24,28,共3页
China Medicine And Pharmacy
基金
全军医药卫生科研基金资助项目(编号:06G029)
