期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

早期抗逆转录病毒治疗改善无症状HIV-1感染者预后 被引量：3

原文传递
导出
摘要 一、概述 抗逆转录病毒治疗（ART）的启动时机是治疗HIV-1（若无特殊说明,以下HIV指HIV-1）感染的核心问题之一,长期处于争论状态. 1987年引入耐受性较差的齐多夫定后,相继出现了支持早期与推迟使用齐多夫定的临床试验[1-2].1996年出现的联合抗逆转录病毒治疗（cART）方案使得人们再次重视早期治疗,1997年国际AIDS协会指南推荐所有可检测到血浆HIV RNA的无症状感染者接受治疗[3].
作者 范思远 弓孟春 杨莹韵 李太生
机构地区 中国医学科学院北京协和医学院北京协和医院内科 中国医学科学院北京协和医学院北京协和医院感染内科
出处 《中华内科杂志》 CAS CSCD 北大核心 2011年第6期526-529,共4页 Chinese Journal of Internal Medicine
关键词 HIV-1感染者 抗逆转录病毒治疗 早期治疗 无症状 预后 齐多夫定 临床试验 AIDS
分类号 R51 [医药卫生—内科学]
  • 相关文献

参考文献37

  • 1Volberding PA,Lagakos SW,Koch MA,et al.Zidovudine in asymptomatic human immunodeficiency virus infection.A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter.The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases.N Engl J Med,1990,322:941-949.
  • 2Volberding PA,Lagakos SW,Grimes JM,et al.A comparison of immediate with deferred zidovudine therapy for asymptomatic HIVinfected adults with CD4 cell counts of 500 or more per cubic millimeter.AIDS Clinical Trials Group.N Engl J Med,1995,333:401-407.
  • 3Carpenter CC,Fisehl MA,Hammer SM,et al.Antiretroviral therapy for HIV infection in 1997.Updated recommendations of the International AIDS Society-USA panel.JAMA,1997,277:1962-1969.
  • 4Yeni PG,Hammer SM,Carpenter CC,et al.Antiretroviral treatment for adult HIV infection in 2002:updated recommendations of the International AIDS Society-USA Panel.JAMA,2002,288:222-235.
  • 5Lampe FC,Gatell JM,Staszewski S,et al.Changes over time in risk of initial virological failure of combination antiretroviral therapy:a muhicohort analysis,1996 to 2002.Arch Intern Med,2006,166:521-528.
  • 6Kitahata MM,Gange SJ,Abraham AG,et al.Effect of early versus deferred antiretroviral therapy for HIV on survival.N Engl J Med,2009,360:1815-1826.
  • 7When To Start Consortium,Sterne JA,May M,et al.Tinting of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients:a collaborative analysis of 18 HIV cohort studies.Lancet,2009,373:1352-1363.
  • 8Strategies for Management of Antiretroviral Therapy (SMART)Study Group,El-Sadr WM,Lundgren JD,et al.CD4 + countguided interruption of antiretroviral treatment.N Engl J Med,2006,355:2283 -2296.
  • 9Study Group on Death Rates at High CD4 Count in Antiretroviral Naive Patients,Lodwick RK,Sabin CA,et al.Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America:a pooled cohort observational study.Lancet,2010,376:340-345.
  • 10Severe P,Juste MA,Ambroise A,et al.Early versus standard antiretroviral therapy for HIV-infected adults in Haiti.N Engl J Med,2010,363:257-265.

二级参考文献36

  • 1王爱霞,王福生,王清玥,王健,冯铁建,卢洪洲,孙洪清,孙永涛,叶寒辉,李太生,李兴旺,刘正印,邢玉兰,何云,汪宁,吴昊,吴南屏,张福杰,周曾全,宫恩聪,赵红心,赵敏,唐小平,徐莲芝,徐小元,曹韵贞,康来仪,蒋岩,蔡卫平,樊庆泊,潘孝彰.艾滋病诊疗指南[J].中华传染病杂志,2006,24(2):133-144. 被引量：631
  • 2Palella FJ Jr,Delaney KM,Moorman AC,et al.Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection.HIV Outpatient study Investigator.N Engl J Med,1998,338:853-860.
  • 3Palella FJ Jr,Baker RK,Moorman AC,et al.Mortality in the highly active antiretroviral therapy era:changing causes of death and disease in the HIV outpatient study.J Acquir Immune Defic Syndr,2006,43:27-34.
  • 4Toro PL,Katyal M,Carter RJ,et al.Initiation of antiretroviral therapy among pregnant women in resource-limited countries:CD4 + cell count response and program retention.AIDS,2010,24:515-524.
  • 5Department of Health and Human Services.Guidelines for the use of antiretroviral agents in HIV-1 -infected adults and adolescents.2009.[2010-05-16].http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.
  • 6European AIDS Clinical Society.Clinical management and treatment of HIV infected adults in Europe.2009.5th ed.[2010-05-18].http://hivpolicy.ru/publications/index.php? id =765&file = 1518.
  • 7World Health Organization.Rapid advice:antiretroviral therapy for HIV infection in adults and adolescents.2009.[2010-05-17].http://www.who.int/hiv/pub/arv/rapid_advice_art.pdf.
  • 8卫生部艾滋病临床专家工作组.国家免费艾滋病抗病毒药物治疗手册.[2010-05-18].http://www.chinaids.org.cn/n16/n1657/n32880.files/n32881.pdf.
  • 9Sax PE,Baden LR.When to start antiretroviral therapy-ready when you are? N Engl J Med,2009,360:1897-1899.
  • 10Bangsberg DR,Acosta EP,Gupta R,et al.Adherence-resistance relationships for protease and non-nucleoside reverse transcriptase inhibitors explained by virological fitness.AIDS,2006,20:223-231.

共引文献630

同被引文献14

引证文献3

二级引证文献8

中华内科杂志
2011年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部