摘要
目的:评价他汀类药物的研究进展,以供临床医师合理用药参考。方法:查阅近年来国内外的相关文献资料,进行归纳和分析。结果与结论:他汀类药物不仅能降低血清胆固醇水平,还通过改善血管内皮功能、抗炎及抗氧化作用、抗血小板聚集和抑制血栓形成、稳定粥样硬化斑块、抑制平滑肌细胞增殖及迁移等其他多效性,在冠状动脉粥样硬化性心脏病、缺血性脑卒中、糖尿病血管病、心律失常、阿尔茨海默病、高血压等心血管疾病中发挥其作用。国内冠心病患者目前他汀类药物的使用状况存在明显不足,说明这方面的循证医学证据还亟待转化为科学规范的临床实践。
OBJECTIVE：To evaluate the research progress on statins in order to provide references for clinicians about rational drug use.METHODS：By reviewing the pertinent literature both at home and abroad,a systematic meta-analysis was performed on the research progress on statins.RESULTS ＆ CONCLUSION：Statins can not only lower cholesterol levels,but also play a role in the treatment of coronary atherosclerotic heart disease,cerebral ischemic stroke,diabetic angiopathy,arrhythmia,alzheimer disease and hypertension etc through ameliorating the endothelial function of blood vessels,inhibiting platelet aggregation and formation of thrombus,stabilizing atherosclerotic plaque,inhibiting proliferation and migration of smooth muscle cells as well as its anti-inflammatory and antioxidative action.In China,statins were poorly used in patients coronary artery disease,indicating the necessity to transform the evidence in evidenced-based medicine in this filed to scientific and standard clinical practice
出处
《中国医院用药评价与分析》
2011年第6期488-493,共6页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
他汀类药物
研究进展
临床应用
不良反应
Statins
Research progress
Clinical application
Adverse drug reaction
