摘要
目的研究在高原地区缺血预处理对大鼠肝脏缺血再灌注的影响。方法本组99只大鼠分为IPC1组、IPC2组及PTC组。观察并统计动物术后12、24、48、72 h存活率。术后12、24、48、72 h分别开腹,取心脏血、肝脏标本进行肝功能及病理检查。比较分析三组的病理改变、死亡率及肝功能指标变化。结果 IPC2组的ALT值及死亡率均明显高于PTC组与IPC1组,IPC1组的病理改变明显轻于IPC2组,而IPC2组与PTC组的病理改变相近。结论在高原地区反复短暂的组织器官缺血可致累加性损伤,最终导致组织坏死,器官功能衰竭。
Objective To research into the effects of ischemic preconditioning（IPC） on hepatic ischemia-reperfusion injury of rats in the plateau region.Methods Totally 99 rats were divided into IPC1 group,IPC 2 group and portal trail clamp（PTC） group.The survival rate were observed and recorded at 12,24,48 and 72 h after surgery respectively.Meanwhile,the blood and tissue samples were collected to do liver function and pathological examinations.The pathological changes,motality rates and changes in liver function were compared among the three groups.Results Alanine aminotransferase（ALT） and mortality rate in IPC2 group were markedly higher than those in PTC group and IPC1 group while the pathological change was more obvious in IPC2 group than that in IPC1 group.The pathological change in PTC group was similar to that in IPC2 group.Conclusion In the plateau region,repeated transient organs ischemia will produce cumulative liver damage,ultimately leading to tissue necrosis and organ failure.
出处
《局解手术学杂志》
2011年第4期357-360,共4页
Journal of Regional Anatomy and Operative Surgery
关键词
高原地区
缺血预处理
肝脏
缺血再灌注
high altitude
ischemic preconditioning
liver
ischemia-reperfusion
