摘要
目的总结胆管癌相关基因甲基化谱的研究进展,阐述DNA甲基化研究对胆管癌的临床诊断价值和治疗意义。方法分析近年来有关胆管癌相关基因异常甲基化与胆管癌关系的文献报道。结果胆管癌的发病是多基因异常表达的结果,目前已发现许多肿瘤相关基因甲基化异常与胆管癌的发生密切相关。表基因的改变可能是胆管癌发生过程中非常重要的机理。结论胆管癌相关基因甲基化异常与胆管癌的发生关系密切,胆管癌相关基因异常甲基化检测有望为胆管癌的早期无创诊断提供新的途径。改变DNA甲基转移酶活性和胆管癌相关基因甲基化状况可作为胆管癌辅助治疗的一种新思路。
Objective Recent advancements in the researches on cholangiocarcinoma（CC） related genes methylation in CC were reviewed and the clinical significances of aberrant DNA methylation for the diagnosis and treatment of CC were discussed.Methods Relevant literatures about the relation between CC-related genes methylation and CC published recently were collected and reviewed.Results The genesis of CC resulted from abnormal expressions of many genes.Many researches had shown that the abnormal methylation of CC-related genes had a close relation with CC.Epigenetic alteration had been acknowledged as an important mechanism contributing to early CC carcinogenesis.Conclusions Abnormal methylation of CC-related genes is related with CC.The detection of CC-related genes methylation might provide new specific biomarkers for early noninvasive diagnosis of this disease.Using epigenetic agents such as azacytidine to modulate the activities of DNA methyltransferase and reverse the methylation status of CC-related gene might be an attractive strategy for future treatment of CC,which could be combined with conventional therapies.
出处
《中国普外基础与临床杂志》
CAS
2011年第6期672-675,共4页
Chinese Journal of Bases and Clinics In General Surgery
基金
四川省科技厅公益性基金资助项目(项目编号:2008SG0028)~~
关键词
DNA甲基化
胆管癌
胆管癌相关基因
诊断与治疗
DNA methylation
Cholangiocarcinoma
Cholangiocarcinoma-related gene
Diagnosis and treatment
