期刊文献+

弓形虫慢性感染对小鼠脑内葡萄糖代谢影响的研究 被引量:8

Effect of latent asymptomatic toxoplasmosis on glucose metabolism in brain of mice
原文传递
导出
摘要 目的探讨弓形虫慢性感染对小鼠脑内葡萄糖代谢的影响。方法将30只SPF级ICR小鼠随机分成弓形虫感染组和正常对照组,感染组每只小鼠口服感染弓形虫PRU株包囊悬液0.3m(l含包囊10个),对照组口服0.3ml生理盐水。小鼠感染弓形虫6个月后,应用MicroPET扫描脑内葡萄糖代谢,结束后解剖小鼠进行脑组织病理学观察。结果与正常对照组小鼠相比,弓形虫慢性感染6个月后,"无症状"的感染小鼠脑内葡萄糖代谢均显著下降,脑组织中可见大小不一、数量不等的包囊,脑膜下有大量淋巴细胞浸润、血管充血、小血管淋巴细胞袖管形成。结论弓形虫慢性感染可造成宿主脑内葡萄糖代谢下降,神经元变性或细胞丢失。 Objective To explore the effect of latent asymptomatic Toxoplasma gondii infection on glucose metabolism in brain of mice. Methods Twenty mice were randomly divided into two groups: a Toxoplasma infected group and normal control group. The mice in the Toxoplasma infected group were inoculated with 0.3 ml of brain suspension in saline containing ten Toxoplasma gondii tissue cysts, avirulent Toxoplasma gondii Prugniaud (PRU, a Type Ⅱ strain). The mice in the control group received 0.3 ml of saline orally. Six monthes after the infection, the glucose metabolism changes in the mouse brain were evaluated by MicroPET, then all the mice were sacrificed and the brain tissues were observed histopathologically. Results Compared with the normal controls, the infected mice demonstrated profound and widespread brain pathology, and MicroPET indicated a significant glucose metabolism reduction in the brain of asymptomatic Toxoplasma gondii infected mice. Conclusion Chronic Toxoplasma gondii infection maybe results in the glucose metabolism reduction in the brain of mice.
出处 《中国血吸虫病防治杂志》 CAS CSCD 北大核心 2011年第3期307-310,F0003,共5页 Chinese Journal of Schistosomiasis Control
基金 江苏省卫生厅基金(X200739)
关键词 弓形虫 正电子发射断层显像 18F-脱氧葡萄糖 葡萄糖代谢 小鼠 Toxoplasma gondii Positron emission tomography (PET) 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) Glucose metabolism Mouse Brain
  • 相关文献

参考文献29

二级参考文献101

共引文献27

同被引文献82

引证文献8

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部