摘要
目的探讨健康志愿者6％羟乙基淀粉130／0．4的容量动力学。方法健康志愿者7名，性别不限，年龄18～32岁，体重46—84kg。经60min静脉输注6％羟乙基淀粉130／0．430ml／kg。采用Matlab6．0版软件包进行容量动力学分析，采用F检验选择房室模型。结果一室模型参数：基础清除率（3．5±1．3）ml／min，清除率（19±11）ml／min，一室模型分布容积（5746±1371）ml；二室模型参数：清除率（63±29）ml／min，交换系数（11±4）ml／min，中央室目标容积（1551±995）rnl，外周室目标容积（908±398）ml，二室模型分布容积（2460±1332）ml。6％羟乙基淀粉130／0．4扩张、转运、分布及消除等体内过程符合容量动力学一室模型（F值为3．81，P〉0．05）。4h清除率为（75±10）％。容量动力学一室模型分布容积与健康志愿者血容量比较差异无统计学意义（P〉0．05）。结论健康志愿者6％羟乙基淀粉130／0．4急性扩容符合容量动力学一室模型，提示羟乙基淀粉快速输注主要分布在血液，有效扩容时间4h。
Objective To investigate the volume kinetics of 6% hydroxyethyl starch 130/0.4 in healthy volunteers. Methods Seven healthy volunteers aged 18-32 yr weighing 46-84 kg were selected in this study. 6 % hydroxyethyl starch 130/0.4 30 ml/kg was infused over 60 min. Volume kinetics analysis of 6% hydroxyethyl starch 130/0.4 was performed with Matlab 6.0 software, compartment model was determined by F test. Results One-compartment model parameters： basic clearance, clearance and distribution volume of one-compartment model were （3.5 ± 1.3） ml/min, （19 ± 11） ml/min and （5746 ± 1371） ml respectively. Two-compartment model parameters ： clearance, K1 , the volume of central compartment, the volume of peripheral compartment, distribution volume of two-compartment model were （63 ± 29） ml/min, （ 11 ± 4） ml/min, （ 1551 ± 995 ） ml, （908 ± 398） ml, （2460 ± 1332） ml respectively. There was no difference between the distribution volume of one-compartment model and blood volume of healthy volunteers （ P 〉 0.05）. The distribution of infused 6 % hydroxyethyl starch 130/0.4 was accordant with one-compartment model （ F value was 3.81, P 〉 0.05）and 4 h clearance was （75 ± 10） % . Conclusion The distribution of infused 6% hydroxyethyl starch 130/0.4 for volume expansion is accordant with one-compartment model, and the effective duration of plasma volume expansion is 4 h.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2011年第4期469-471,共3页
Chinese Journal of Anesthesiology
