摘要
目的 食管癌化疗序贯放疗和单纯放疗疗效对比研究。方法 ２４８ 例食管癌随机分为综合治疗组１２５ 例和单纯放疗组１２３ 例。综合组：ＤＤＰ（５０ｍｇｍ２ ，Ｄ１ ，８）５ＦＵ（７５０ｍｇｍ２ ，Ｄ２６） 静脉注射，３ 周为一周期，潘生丁５０ｍｇ，口服，每天三次。２３ 周期化疗后放疗（ＤＴ６０７０Ｇｙ６－５７－５周） 。单纯放疗组直接放疗（ＤＴ６０７０Ｇｙ６－５７－５ 周） 。结果 两组近期疗效无明显差别，综合组完全缓解率及１ ，３，５ 年生存率高于单纯放疗组（ｐ ＜ ０－０５） 。结论 化疗后序贯放疗是治疗食管癌安全有效的方法。
Objective to compare the effect of chemo raditherapy and single radiotherpy to esophageal cancer.Methods 248 patients with esophageal cancer were randomly divided into the combination treatment group of 125 cases and single radiotherpy group of 123 cases.In combined group,DDP(50mg/m 2,day1,8)and 5 Fu(750mg/m 2,day 2～6)were administered by IV per three weeks,persantin 50mg po three times a bay,radiotherpy(DT60～70GY/6 5～7 5 weeks)followed 2～3 cycle chemotherapy later.Single radiotherpy group were treated by radiation(DT60～70GY/6 5～7 5 weeks)only.Results The comparative observation of the two groups showed that:the short term effects were similar, in the combined therapy group,the patients of complete remission and 1 year,3 year,5 year survival rates was higher than single radiotherapy group (p<0 05).Conclusion Chemotherapy radiotherayp sequential therapy is effective and safety method for the patients of esophageal carcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第5期376-377,共2页
Cancer Research on Prevention and Treatment
关键词
食管癌
药物疗法
放射疗法
esophageal carcinoma
chemo radiotherapy
response rate survival rate
