摘要
目的观察牙齿移动过程中咖啡因对牙槽骨改建的影响。方法建立大鼠正畸牙移动模型,分别按照每日10mg/100 g、2.5mg/100g给予咖啡因,在加力前及加力后第1天,第3天,第7天,第14天,第21天和第28天处死大鼠,通过H-E和TRAP染色观察牙周组织变化情况,行破骨细胞计数。结果每日10mg/100g组压力侧破骨细胞数量多于对照组和每日2.5mg/100g组,牙槽骨吸收明显;而张力侧成骨作用不活跃,新生骨不如对照组和每日2.5mg/100g组明显。结论牙齿移动过程中适当饮用咖啡因对牙槽骨的代谢没有明显影响,而大量饮用咖啡因则对骨的代谢具有潜在的影响,可能影响牙槽骨的改建。
Objective To investigate the effect of caffeine on alveolar bone remodeling during orthodontic tooth movement in rats. Methods Fifty-four male Sprague-Dawley rats were randomly divided into three groups： group A （n = 18） in which animals did not received caffeine ingestion; high and low dose caffeine groups（group B and C, n = 18 in each group） in which animals ingesting l0 mg or 2.5 mg/100 g body weight of caffeine via drinking water everyday. The upper right first molars were moved orthodontically by using a coil spring. The rats were sacrificed in 1,3,7,14,21 and 28 d after given caffeine in drinking water. Tissue sections were observed underligbt microscope after haematoxylin-eosin（H-E） and tartrate-resistant acid phosphatase （TRAP） histochemistry. Results The result shown a significant increase number of osteoclast cells in the compression side and decrease osteoblast cells in the tention side in high-dose caffeine group compared with low dose caffeine and non-caffeine groups. Conclusion The present study indicated that daily intake of high doses caffeine may have an effect on the alveolar bone remodeling during orthodontic tooth movement.
出处
《同济大学学报（医学版）》
CAS
2011年第3期24-27,共4页
Journal of Tongji University(Medical Science)
关键词
咖啡因
牙槽骨
正畸
牙齿移动
大鼠
caffeine
alveolar bone
orthodontic
tooth movement
rats
