摘要
阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea—hyponea syndrome，OSAHS）可导致肾脏损伤。OSAHS对肾脏的影响可表现为肾小球滤过率降低、肾小球超滤过、蛋白尿，夜尿增多、尿电解质排泄增多，血管活性物质分泌增多及促红细胞生成素分泌增多。组织学改变可表现为肾小球肥大、局灶节段性肾小球硬化、近曲小管上皮细胞变性。持续气道正压通气治疗可延缓OSAHS的肾脏损伤。现就OSAHS对肾脏的影响作一综述.
Obstructive sleep apnea-hypopnea syndrome （OSAHS）can lead to renal indury. The impact of OSAHS on kidneys involves reduced glomerular filtration rate, glomerular byperfiltration, proteinuria, increased nocturia, increased excretion of urinary electrolytes, increased secretion of vasoactive substances and EPO. Renal histology shows glomerulomegaly, focal segmental glomerulosclerosis and the degeneration of proximal tubular epithelial cells. CPAP treatment can ameliorate the renal indury. This article reviews on the impact of OSAHS on kidneys.
出处
《国际呼吸杂志》
2011年第13期1025-1029,共5页
International Journal of Respiration
