摘要
目的:观察放疗联合培美曲赛和顺铂同期化疗治疗局部晚期非小细胞肺癌的临床副反应,探讨有效的护理对策。方法:22例经病理证实的局部晚期非小细胞肺癌患者,给予调强适形放疗并同期联合培美曲赛和顺铂化疗,采用RTOG和CTC AE3.0标准评价副反应,给予放疗护理、化疗护理、中心静脉导管护理、疲劳护理等措施干预。结果:22例患者出现骨髓抑制18例,发生率81.8%;胃肠道反应8例,发生率36.3%;疲劳22例,发生率100%;放射性食管炎12例,发生率54.5%;放射性肺炎7例,发生率31.8%;其他不良反应有口腔黏膜反应、发热、皮疹、脱发等,发生率40.9%。经及时给予对症处理和有效的护理措施干预后缓解,22例患者全部顺利完成治疗。结论:培美曲赛和顺铂同期放疗治疗局部晚期非小细胞肺癌,患者副反应可耐受,给予积极有效的护理措施干预,可减轻副反应,促其顺利完成治疗,提高生活质量。
Objective： To observe the side effect of concurrent pemetrexed plus eisplatin chemotherapy and radiotherapy for locally advanced non-small cell lung cancer and discuss effective nursing measures. Methods： Twenty-two patients with locally advanced non-small cell lung cancer confirmed by pathology received intensity modulated irradiation combined with pemetrexed plus cisplatin chemotherapy. RTOG and CTC AE3.0 standards were used to evaluate side effects. Timely nursing interventions such as radiotherapy care, chemotherapy care, central venous catheter care and fatigue care were provoided. Results： Myelosuppression occurred in 18 patients of the whole 22 patients（81.8% ）, gastrointestinal reaction in 8 patients with the incidence of 36. 3%, fatigue in 22 patients （ 100% ）, radiation esophagitis in 12 patients with the incidence was 54. 5%, radiation pneumonitis in 7 patients（ 31.8% ）. Other ad- verse reactions included oral mucositis, fever, rash and alopecia with the incidence of 40. 9%. Being given timely symptomatic treatment and effective nursing intervention, all patients finished the whole therapeutic procedure smoothly. Conclusion： Side effects of concurrent pemetrexed plus cisplatin chemotherapy and radiotherapy for locally advanced non-small cell lung cancer were tolerable. Active and effective nursing interventions can reduce side effects and promote the completion of treatment as well as improve life quality of patients.
出处
《肿瘤预防与治疗》
2011年第4期182-185,共4页
Journal of Cancer Control And Treatment
关键词
非小细胞肺癌
放化疗
培美曲赛
顺铂
护理
Non-small Cell Lung Cancer
Chemoradiotherapy
Pemetrexed
Cisplatin
Nursing
