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HPLC法测定小儿智力糖浆中细叶远志皂苷的含量 被引量:6

Determination of Tenuifolin in the children intelligence syrup by HPLC
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摘要 目的:建立小儿智力糖浆中细叶远志皂苷的含量测定方法。方法:采用HPLC法测定。色谱柱:E2111646Z C18柱(4.6 mm×250 mm,5μm),流动相:甲醇-0.05%磷酸溶液(70∶30),流速:1.0 ml/min,检测波长:210 nm,理论板数按细叶远志皂苷峰计算不应低于3 000。结果:细叶远志皂苷在30.4~608μg/ml范围内呈良好的线性关系;平均加样回收率为99.20%,RSD=0.95%(n=5)。结论:该方法简便,结果准确,重现性好,可作为小儿智力糖浆质量控制方法。 Objective:To establish a method for determination of the tenuifolin in the children intelligence syrup by HPLC.Methods:E2111646Z C18 column(4.6 mm ×250 mm,5 μm) was used,the mobile phase consisted of methanol-0.05% phosphoric acid solution(70∶30,V/V),flow rate was 1.0 ml/min,and the detective wavelength was 210 nm,theoretical tower number calculated by tenuifloin peak should not under the level of 3 000.Results:There were good straightness performance when the concentration of tenuifolin between 30.4 to 608 μg/ml.The average recovery of tenuifolin was 99.20% and the RSD was 0.95%(n=5).Conclusion:This method is simple and convenient.The accurate result and reappearing feature will be regarded as the quality control method of children intelligence syrup.
出处 《中国医药导报》 CAS 2011年第19期60-61,共2页 China Medical Herald
关键词 小儿智力糖浆 远志 细叶远志皂苷 HPLC 含量测定 Children intelligence syrup Radix Polygalae Tenuifolin HPLC Determination
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