摘要
采用合成法测定了醋酸可的松在乙酸乙酯、丙酮、1,4-二氧六环、DMF、乙醇中的溶解度.通过Apelblat方程和λh方程对所测实验数据进行了关联,并取得了较好的关联结果,且Apelblat方程优于λh方程.结果表明,它在五种溶剂中的溶解度都随温度升高而增大,在1,4-二氧六环、丙酮和DMF中对温度比较敏感.本研究不仅为醋酸可在松结晶过程中的溶剂选择提供了基础数据,同时也为醋酸可的松的工业生产、回收、提纯以及理论研究提供了重要的固液相平衡数据.
The solubilities of cortisone acetate in ethyl acetate,acetone,1,4-dioxane,DMF and ethanol were determined with the synthetic method.The experimental data were correlated with the Apelblat equation and the λh equation,which showed good correlation results.And the correlation results of the Apelblat equation were better than those of λh equation.The results show that the solubility of cortisone acetate in above five solvents increases with the increase of temperature,the temperature sensitivity is high in the 1,4-dioxane,acetone and DMF.This study provides essential data for the solvent selection in the process of cortisone acetate crystallization,as well as the significant solid-liquid equilibrium data for its industrial production,recovering,purifying,and its theoretical studies.
出处
《郑州大学学报（工学版）》
CAS
北大核心
2011年第3期31-35,共5页
Journal of Zhengzhou University（Engineering Science）
基金
河南省高校科技创新人才支持计划项目(2010HASTIT037)
