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血浆与浓缩红细胞的比例对产后大出血患者凝血功能的影响 被引量:7

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摘要 目的探讨产后大出血时输注血浆与浓缩红细胞的比例差别对于产妇凝血功能的影响,为防治凝血功能障碍提供依据。方法选择2002年1月至2010年1月产后大出血需要输血的产妇40例为研究对象,按输血成份不同分两组,对照组(10例)输注悬浮红细胞,实验组(30例)以新鲜冰冻血浆:悬浮红细胞=1:1作为分界,又分为高(〉1:1)、中(1:1)、低(〈1:1)三个亚组,每组10例。对各组输血前后分别进行凝血酶原时间(阿)、活化部分凝血活酶时间(APTr)、凝血酶时间(1Tr)、纤维蛋白原(FIB)含量测定,比较血浆与浓缩红细胞的比例差别对于产后大出血患者凝血功能的影响。结果两组患者大量输注悬浮红细胞前凝血功能均正常(P〉0.05),大量输注悬浮红细胞24h后,对照组凝血酶原时间、活化部分凝血活酶时间、凝血酶时间明显延长,纤维蛋白原含量明显降低实验组(P〈0.05);低比例组大量输血后凝血酶原时间、活化部分凝血活酶时间延长(P〈0.05),纤维蛋白原下降(P〈0.05);中比例和高比例组输血后凝血酶原时间、活化部分凝血活酶时间、凝血酶时间,纤维蛋白原仍在正常水平(P〉0.05)。结论产后大出血病人大量输注悬浮红细胞时会影响凝血功能,而输入新鲜冰冻血浆与悬浮红细胞的比例≥1:1,既能改善产妇的凝血功能,又减少其不良出血事件的发生率。·
作者 韩驰
出处 《中国医师杂志》 CAS 2011年第6期836-838,共3页 Journal of Chinese Physician
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