摘要
目的以司帕沙星(SF)为模型药物,制备耳用脂质体-原位凝胶(ISG),并对其体外释药行为进行考察。方法采用薄膜分散法制备SF脂质体(SFL),并选用泊洛沙姆407为基质,制备温敏性耳用ISG(SFL-ISG),采用无膜溶出模型对其体外释放行为进行考察,并与司帕沙星原位凝胶(SF-ISG)进行比较。结果 SFL-ISG中SFL的粒径分布均匀,平均粒径为(836.8±54.5)nm,体外药物释放、凝胶溶蚀均符合零级动力学特征,方程分别为y=3.0870x-5.2581(r=0.997 8),y=0.2299x+1.6892(r=0.997 3)。结论 SFL-ISG制备简单,胶凝温度适宜,并可延缓药物释放,值得进一步研究。
Objective To prepare liposomal in-situ gel（ISG） for ear with sparfloxacin（SF）as the model drug,and investigate the drug release in vitro.Methods SF liposomes（SFL） were prepared by the film dispersion method.Poloxamer 407 was used as themosensitive material for the SFL-ISG.A membraneless model was used to study in vitro release of the drug and compared with that of ISG containing SF only（SF-ISG）.Result SFL in SFL-ISG was uniformly distributed with mean size of（836.8±54.5） nm.The properties of the drug release in vitro and gel corrosion were in consistence with zero-order kinetics with the equation of y=3.0870x-5.2581（r=0.997 8）and y=0.2299x＋1.6892（r=0.997 3）,respectively.Conclusion SFL-ISG can be prepared easily with suitable gelation temperature,and it may delay the drug release,which is valuable to study further.
出处
《广东药学院学报》
CAS
2011年第3期224-226,共3页
Academic Journal of Guangdong College of Pharmacy
关键词
司帕沙星
脂质体
原位凝胶
体外释药
sparfloxacin
liposomes
in-situ gel
in vitro release of the drug
