摘要
目的观察比较伊布利特与胺碘酬转复心房扑动/心房颤动的临床疗效。方法将符合入选标准的29例房扑/房颤患者随机分为伊布利特组(n=15)及胺碘酮组(n=14)。伊布利特1mg于15分钟内静注;如无效10分钟后再给予1mg静注;胺碘酮150mg于15分钟内静注;如无效10分钟后再给予75rng静注。结果伊布利特组转复心房扑动/心房纤颤时间明显短于胺碘酮组;伊布利特组与胺碘酮组分别有9例与5例在给药后0～90分钟内转复为窦性心律,转复率为64.29%和33.33%;伊布利特组与胺碘酮组分别有3例与4例在给药后90分钟至4小时内转复为窦性心律,转复率为60.0%和50.0%。两组相比,差异具有显著性。结论伊布利特转复房扑/房颤的疗效高于胺碘酮,时间短于胺碘酮。
Objective To compare the effect of ibutilide and amiodarone in the conversion of atrial fibrillation （AF） or atrial flutter （AFL）. Methods 29 cases of AF/AFL patients were randomly divided into ibutilide group （n = 14） and amiodarone group （n = 15 ）. Ibutilide group received I mg ibutilide within 15 min, followed by a further 1 mg if AF/AFL persisted 10 min after the first dosage. Patients in the amiodarone group received 150 mg amiodarone,the 75 mg was repeated if AF/AFL was not converted 10 min after the first dosage. Results Ibutilide had a significantly fast converting time than amiodarone. The number of successful converting in two groups were counted in 0 - 90 min and 90 min -4h after administration. Nine patients with AF/AFL were converted in group ibuti/ide and 5 in group amiodarone in 0 - 90 min after administration. Three patients were converted in group ibutilide and 5 in group amiodarone in 90 min - 4h. Conclusion Ibutilide is more effective and quicker than amiodarone when administered to convert AF/AFL to sinus rhythm.
出处
《中国医刊》
CAS
2011年第7期44-45,共2页
Chinese Journal of Medicine
