摘要
目的:探讨神经生长因子、被动运动对失神经大鼠股骨生物力学性能的影响。方法:去除坐骨神经和股神经造大鼠股骨废用性骨质疏松模型,将大鼠随机分为假手术组(SHAM组)、去神经对照组(DN组)、神经生长因子组(NGF组)、被动运动组(PM组)、神经生长因子+被动运动组(NGF+PM)组,观察各组大鼠股骨生物力学指标的变化。结果:NGF+PM组股骨最大载荷、结构刚度、破断载荷、最大应变、弹性模量、极限强度与DN组相比差异均具高度显著性(P<0.01);而与SHAM组相比差异不具显著性(P>0.05),NGF组结构刚度、弹性模量、极限强度低于SHAM组(P<0.05),最大载荷指标明显低于SHAM组(P<0.01);PM组最大载荷低于SHAM组(P<0.05),其余指标差异不显著。结论:大鼠股骨失神经支配后骨生物力学性能下降,神经生长因子和被动运动均可减缓失神经大鼠股骨生物力学性能的改变,两种方法合用能更有效防治大鼠失神经所致的废用性骨质疏松。
Objective：to investigate the effect of exogenous nerve growth factor（NGF） and passive action on the biomechanics of denervated rats with disuse osteoporosis.Methods：rats were randomly divided into five groups（Sham group,DN group,NGF group,PM group and NGF＋PM group）.Results：compared with sham group,the biomechanical indices were in the denervation group（P0.01）.The maximum load and modulus of elasticity in the combination group were both decreased（P0.05）.In the PM＋NGF Group,the maximum load,structure stiffness and modulus of elasticity were all reduced（P0.05）.Conclusion：after the denervation,the muscular stress has been lost and femoral mechanical property decrease,nerve repair and regeneration will benefit to prevent or delay the appearance of osteoporosis.
出处
《成都体育学院学报》
CSSCI
北大核心
2011年第6期67-70,共4页
Journal of Chengdu Sport University
