摘要
目的了解ICU患者真菌肺部感染的菌种分布,为临床治疗真菌肺部感染提供依据。方法回顾性分析某医院ICU病房2008年8月-2010年8月间患者真菌引起肺部感染的真菌构成、真菌耐药特征与临床治疗转归。结果 852例ICU患者中,87例患者发生了真菌性肺部感染,共检出9类91株真菌,白色念珠菌是引起ICU患者肺部感染最主要的真菌。91株真菌对咪康唑、益康唑、酮康唑、氟康唑、5-氟胞嘧啶、两性霉素B、制菌霉素的耐药率分别为26.37%、23.08%、16.48%、26.37%、18.68%、5.49%、9.89%。87例肺部真菌感染患者中有19例患者死亡。结论真菌引起的肺部感染具有较高的耐药性,临床危害大,是ICU患者死亡的重要因素之一,应引起临床的高度重视。
Objective To investigate the clinical distribution of fungus in ICU patients with pulmonary fungal infection（PFI）,and to provide the evidence for clinical treatment of PFI.Methods The fungi species,drug resistance features and clinical therapeutic outcomes of 852 ICU patients with PFI in the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from August,2008 to August,2010 were retrospectively analyzed.Results Of the 852 patients,87 patients suffered from PFI,and totally 91 strains of fungi were detected.Candida albicans was the main pathogen that caused PFI among ICU patients.The drug resistance rates of 91 strains of fungi against miconazole,econazole,ketoconazole,fluconazole,5-flucytosine（5FC）,amphotericin B,and nystatin were 26.37%,23.08%,16.48%,26.37%,18.68%,5.49%,and 9.89%,respectively.There were 19 death cases among the 87 patients with PFI.Conclusions Pulmonary infection caused by fungus displays high level of drug resistance and has a severe outcome.It is one of the important factors in the death of ICU patients and the clinicians should pay more attention to it.
出处
《实用预防医学》
CAS
2011年第6期1114-1115,共2页
Practical Preventive Medicine
关键词
重症监护病房
肺部感染
真菌
病原学
Intensive care unit（ICU）
Pulmonary infection
Fungus
Etiology
