透析方式对尿毒症患者血清糖基化终产物的影响及相关研究被引量：2

Influence of Dialysis Modality on Advanced Glycation End Products in Uremic Patients

下载PDF

导出

摘要目的比较血液透析(HD)、血液透析滤过(HDF)和血液灌流+血液透析(HP+HD)3种血液净化方式对维持性血液透析患者糖基化终产物(AGEs)、肌酐(BUN)和尿素氮(Cr)清除的影响。方法将48例维持性血液透析患者按随机数字表法分成HD组、HDF组、HP+HD组,每组16例。在透析前后分别取血检测患者AGEs、BUN及Cr。结果 3组患者透析前后比较BUN及Cr均明显下降(P<0.01)。HDF组和HP+HD组患者透析前后AGEs显著下降(P<0.01),而HD组透析前后AGEs差异无统计学意义(P>0.05)。结论 HD、HDF、HP+HD均能有效地清除维持性血液透析患者血液中小分子溶质,而HDF、HP+HD对AGEs清除能力明显优于HD。 Objective To compare the effects of different dialysis modes on serum blood urea nitrogen（BUN）,creatinine（Cr） and advanced glycation end products（AGEs）.Methods Forty-eight maintenance hemodialysis patients were randomly assigned to hemodialysis（HD） group,hemodiafiltration（HDF） group and hemoperfusion plus hemodialysis（HP＋HD） group.Serum BUN,Cr and AGEs were examined before and after dialysis.Results Serum BUN and Cr levels reduced through dialysis in three groups（P0.01）.The concentration of serum AGEs significantly decreased after the dialysis session in HDF group and HP＋HD group（P0.01）,while no significant change in AGEs levels was found in HD group（P0.05）.Conclusion HD,HDF or HP＋HD can efficiently eliminate the low molecular weight solutes,while HDF and HP＋HD are more efficient in AGEs elimination than HD in maintenance hemodialysis patients.

作者罗宇鸿张洪海付俊陆建枫陈菊艳

机构地区无锡市中医院ICU 上高县人民医院检验科

出处《南昌大学学报（医学版）》 CAS 2011年第3期28-30,共3页 Journal of Nanchang University：Medical Sciences

关键词维持性血液透析患者糖基化终产物血液透析血液透析滤过血液灌流+血液透析 maintenance hemodialysis patients advanced glycation end products hemodialysis hemodiafiltration hemoperfusion plus hemodialysis

分类号 R692.5 [医药卫生—泌尿科学]

引文网络
相关文献

参考文献8

1苏晓燕,黄湖辉,李劲高,宛霞.血液透析与透析滤过对中小分子物质清除的比较[J].岭南急诊医学杂志,2006,11(5):323-325. 被引量：5
2赵慧萍,徐学明.慢性肾衰竭血清晚期糖基化终产物水平的变化及意义[J].中国血液净化,2002,1(12):7-11. 被引量：7
3Rashid G,Korzets Z,Bernheim J.Advanced glycation end products stimulate tumor necrosis factor-alpha and interleukin-1beta secretion by peritoneal macrophages in patients on continuous ambulatory peritoneal dialysis. The Israel Medical Association Journal . 2006
4Kawada N,Moriyama T,Ando A,et al.Increased oxidative stress inmouse kidneys with unilateral ureteral obstruction. Kidney International . 1999
5Dumitriu IE,Baruah P,Valentinis B,et al.Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products. J Immunol . 2005
6Machado AP,Pinto RS,Moyses ZP , et al.Aminoguanidine and metformin prevent the reduced rate of HDL mediated cell cholesterol efflux indrced by formation of advanced glycation end products. International Journal of Biochemistry Cell Biology The . 2006
7NOMURA S,SHOUZU A,OMOTO S,et al.Activated platelet and oxidized LDL induce endothelial membrane vesiculation:clinical significance of endothelial cell-derived microparticles in patients with type2diabetes. Clinical and Applied Thrombosis . 2004
8Basta G,Schmidt AM,De Caterina R.Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovascular Research . 2004

二级参考文献15

1胡伟新,唐政.糖基化终末期产物的基础与临床[J].肾脏病与透析肾移植杂志,1995,4(3):245-251. 被引量：5
2[1]R.Dolhofer-Bliesener, Lechner B, Deppisch R, et al. Immunological determination of advanced glycosylation end-products in human blood and urine. Nephrol Dial Transplant, 1995,10:657-664
3[2]Ritz E, Deppisch R, Nawrath P, et al. Toxicity of uraemia-does it come of AGE ? Nephrol Dial Transplant, 1994, 9(1): 1-2
4[3]Friedman EA. Advanced glycation end-products in diabetic nephropathy. Nephrol Dial Transplant 1999,14 Suppl 3:1-9
5[4]Schinzel R, Munch G, Heidland A, et al. Advanced glycation end products in end-stage renal disease and their removal. Nephron 2001,87(4):295-303
6[5]Miyata T, Maeda K, Kurokawa K, et al. Oxidation conspires with glycation to generate noxious advanced glycation end products in renal failure. Nephrol Dia Transplant, 1997,12: 255-258
7[6]Meng J, Sakata N, Imanaga Y, et al. Evidence for a link between glycoxidation and lipoperoxidation in patients with chronic renal failure. Clin Nephrol 1999,51(5):280-9
8侯芳玉,李才,苗春生,等.抗晚期糖化终产物抗体的制备[J].中国实验诊断学,1998,2(5):262.
9[8]Nashino T, Horyy Y, Shiiki H, et al. Immunochemical detection of advanced glycosylation end-products within the vascular leisions and glomeruli in diabetic nephropathy. Hum Pathol,1995,26:308-313
10[10]Papanastasiou P, Grass L, Rdela H. Immunological quantification of advanced glycosylation end-products in the serum of patients on hemodialysis or CAPD. Kidney Int, 1994,46(1):216-222