摘要
目的观察肺PS治疗新生儿呼吸窘迫综合征的疗效。方法对笔者所在医院新生儿特护病房收住的22例新生儿呼吸窘迫综合征患儿使用PS,观察其治疗后的临床反应、血气变化及胸片肺透亮度的变化情况。结果应用PS后,可发现患儿皮肤迅速转红,血氧饱和度上升,不进行机械通气的患儿呻吟、气促情况缓解,呼吸困难、三凹征、紫绀症状减轻或消失;辅助机械通气的患儿用药后30min均下调呼吸机参数,生命体征监测平稳,6～12h复查胸片,肺透亮度明显好转。用药前与用药后2h查血气,pH、PCO2、PO2均有显著差异。结论使用外源性PS替代疗法治疗新生儿呼吸窘迫综合征,减少了NRDS的发病率及疾病的严重程度,降低了呼吸机使用条件,降低了病死率,疗效较好。
Objective To observe the effects of pulmonary surfactant for neonatal respiratory distress syndrome. Methods 22 cases of neonatal respiratory distress syndrome were given pulmonary surfactant. Observe the changes of clinical response, blood gas and lung transderma｜ brightness of chest film between pre-treatment and post-treatment. Results Children patients, dyspnea, tri-retraction sign and cyanotic symptoms reduced or disapeared after application of pulmonary surfactant. And the skin of infantile disease turned red rapidly, Saturation of blood oxygen upgrade. Groan and accelerated breathing relieved of infantile disease that not-aided with machinery Ventilation. Aided with machinery, respiratory ventilation parameters decreased after usinng medicine for 30rain. Monitoring vital signs were steady. After 6-12 hours, checking sternite, brightness of lung obviously improved. Before medication and two hours after medication, checking blood gas, pH, PCO2, PO2 had significant differences between pre and post medication. Conclusion Exogenous pulmonary surfactant replacement therapy had better effect for neonatal respiratory distress syndrome. It reduced incidence and severe degree of NRDS. It also reduced working condition of breathing machine and rate of case fatality.
出处
《中国医药科学》
2011年第12期57-58,共2页
China Medicine And Pharmacy
