摘要
目的:研究胆石六号汤剂的镇痛作用,并观察其对肝功能的影响。方法:取小鼠分为生理盐水空白对照组、阳性对照组、胆石六号汤剂高、中、低剂量组,采用化学刺激方法,观察胆石六号汤剂的镇痛作用;通过对小鼠的眼球采血,观察胆石六号汤剂对血液生化指标的影响。结果:胆石六号汤剂对醋酸所致小鼠扭体反应有明显的抑制作用;在小鼠血液生化指标中,胆石六号汤剂降低丙氨酸氨基转移酶(ALT)、门冬氨酸转移酶(AST),增加血清总蛋白(TP),但对白蛋白(ALB)及球蛋白(GLO)未见明显影响。结论:胆石六号汤剂具有镇痛作用,而且具有保护肝功能的潜在作用。
OBJECTIVE To study the analgesic effect of Bilestone 6th Decoction and its influence on liver function. METHODS The mice were divided into saline control group,positive control group,gallstones on Bilestone 6th Decoction of high,medium and low dose groups. By using the chemical stimulation to observe the analgesic effect of decoction of Bilestone 6th Decoction; and using mice eye blood,the blood biochemical indexes were observed. RESULTS The data showed that Bilestone 6th Decoction significantly attenuated writhing induced by acetic acid. Meanwhile, Bilestone 6th Decoction decreased alanine aminotransferase （ALT） and aspartate aminotransferase （AST） activities, but increased total protein （TP） in serum in mice. However,Bilestone 6th Decoction did not affect albumin （ALB） and globulin （GLO） levels. CONCLUSION Bilestone 6th Decoction may own analgesic effect,and have liver-protective potential effect.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第13期1058-1060,共3页
Chinese Journal of Hospital Pharmacy
基金
贵州省科学技术基金项目(编号:黔科合J字[2008]2151号)
关键词
胆石六号汤剂
镇痛
肝功能
小鼠
Bilestone 6th Decoction
analgesia
liver function
mouse
