摘要
目的系统评价金属-金属与金属-聚乙烯两种髋关节假体的临床疗效。方法计算机检索MEDLINE、EMBASE、Cochrane图书馆、Cochrane协作网肌骨创伤组试验数据库和中国生物医学文献数据库，手工检索相关骨科杂志及会议资料。收集所有比较金属．金属与金属-聚乙烯髋关节假体临床疗效的随机对照试验及半随机对照试验等，评价纳入研究的方法学质量，并使用RewMan4．2．8统计学软件对结果进行Meta分析，比较金属-金属假体与金属-聚乙烯假体髋关节置换术后髋关节Harris评分、髋关节活动范围、假体周围透亮带、脱位及再手术的发生率、血液及尿液中金属离子的浓度。结果共纳入9个研究，其中4篇随机对照试验，5篇临床对照研究。两组患者术后髋关节Harris评分、髋关节活动范围比较差异均无统计学意义（RR=-1．12，95％C1—2．91-0．66，P=0．22；RR=-0．10，95％CI-0．31～0．11，P=0．35）。金属-金属组术后假体周围出现放射透亮带的例数较金属-聚乙烯组少，差异有统计学意义（RR=0．62，95％C10．51～0．76，P〈0．001）；术后发生脱位及再次手术的例数较金属-聚乙烯组少，但差异无统计学意义（RR=0．42，95％C10．11～1．57，P=0．20）；术后血液中金属离子浓度高于金属-聚乙烯组，差异有统计学意义（RR=2．27，95％C11．56～2．98，P〈0．001）；术后尿液中金属离子浓度也较金属-聚乙烯组高，但差异无统计学意义（RR=1．44，95％CI～0．27～3．14，P=0．10）。结论两种髋关节假体术后髋关节功能无明显差异，但金属-金属假体术后假体周围出现放射透亮带的例数较金属-聚乙烯假体少，血液中金属离子浓度较金属，聚乙烯假体高。
Objective To evaluate clinical outcomes of primary cementless total hip arthroplasty with metal-on-metal versus metal-on-polyethylene prostheses. Methods We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialized Register, the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and CBM, conference proceedings and reference lists of articles for ran- domised or quasi-randomised controlled trials comparing metal-on-polyethylene （MOP group） with met- al-on-metal （MOM group） in cementless total hip arthroplasty. The Cochrane Collaboration＇s tool for assessing risk of bias and software RewMan 4.2.8 were used to evaluate methodological quality and to perform a system review. Results Altogether 4 randomised controlled trials and 5 clinical controlled trials were included in this study. Pooled results from all the 9 trials showed no statistical differences between the 2 groups in terms of functional status （Harris hip score） and range of motion （ RR = - 1.12, 95% CI - 2.91 to 0. 66, P = 0.22; RR = - 0. 10, 95% CI- 0. 31 to 0. 11, P = 0.35）. However the cases of periprosthetic radiolucency in the MOP group were significantly more than in the MOM group （ RR = 0.62, 95% CI 0. 51 to 0.76, P 〈 0. 001） . Dif- ferences in the rate of postoperative dislocation or surgical revision were not statistically significant between the 2 groups（ RR = 0.42, 95% CI 0. 11 to 1.57, P =0. 20）, although lower in the MOM group. Serum ion concentrations of cobalt and chromium were significantly higher in the MOM group （RR = 2.27, 95% CI 1.56 to 2.98, P 〈 0. 001 ）, but differences in the urine ion concentrations were not statistically significant （ RR = 1, 44, 95% CI -0. 27 to 3. 14, P = 0. 10） . Conclusions MOM implements may lead to higher serum metal ion concentrations and fewer cases of periprosthetic radiolucency than MOP ones. But both prostheses are similar in hip functional outcomes.
出处
《中华创伤骨科杂志》
CAS
CSCD
2011年第7期613-619,共7页
Chinese Journal of Orthopaedic Trauma
