摘要
目的探讨不稳定性心绞痛(unstable angina pcetoris,UAP)患者血清生长分化因子15(GDF-15)与TIMI危险评分的相关性。方法采用酶联免疫吸附法(ELISA法)检测97例UA患者与30例健康体检者血清GDF-15的表达水平。采用TIMI危险评分方法将UA患者分为3组,比较各组间GDF-15表达水平差异。分析GDF-15与TIMI危险评分的相关性。结果 UA患者血清GDF-15的表达水平显著高于健康体检者,差异有统计学意义(P<0.01);不同TIMI危险评分分组之间血清GDF-15表达水平比较,差异有统计学意义(P<0.01);血清GDF-15表达水平与TIMI危险评分之间存在相关关系。结论血清GDF-15的表达水平可以作为UA患者危险分层评估指标。
Objective To explore the correlation between serum levels of growth differentiation factor-15（GDF-15） and Thrombolysis in Myocardial Infarction（TIMI） risk scores in patients with unstable angina pectoris（UA）.Methods The serum levels of GDF-15 in 97 patients with UA and 30 healthy volunteers were measured using enzyme-linked immunosorbent assay（ELISA） and compared between 3 patient groups with different TIMI scores to analyze relationship between serum GDF-15 levels and TIMI risk scores.Results The serum levels of GDF-15 in UA patients were significantly higher than those in the healthy volunteers（P〈0.01）.GDF-15 levels also differed significantly between patients with different TIMI scores（P〈0.01）,and showed a significant positive correlation to TIMI risk scores.Conclusion Serum levels of GDF-15 can be used as an index for evaluating the severity of UA.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2011年第7期1277-1278,共2页
Journal of Southern Medical University
关键词
不稳定性心绞痛
生长分化因子15
TIMI危险评分
unstable angina pectoris
growth differentiation factor-15
Thrombolysis in Myocardial Infarction risks core
