摘要
随着纳米技术及其应用的迅速发展,纳米材料对生命体和生态环境的影响引起了社会公众、纳米产品生产厂家、科研工作者和各国政府的密切关注。纳米毒理学已成为纳米技术和毒理学的重要分支。纳米毒理学研究依赖于多种分析方法,用于纳米材料物理化学特性的表征及检测生命体中的纳米材料。放射分析方法由于其高灵敏度、高准确度、原位和体内分析能力,在纳米毒理学研究中能够发挥重要作用。本文综述了放射分析方法在纳米毒理学研究中应用的最新进展,重点介绍了针对不同纳米材料的放射性标记技术。
With the rapid development of nanotechnology and its applications,the potential interactions of nanomaterials with living systems and environment have attracted increasing attention from the public,manufacturers of nanomaterial-based products,academic researchers and policymakers.Nanotoxicology is emerging as an important subdiscipline of nanotechnology as well as toxicology.Nanotoxicology studies rely on many analytical methods for the characterization of nanomaterials and detection of nanomaterials in living systems.In this case,radioanalytical methods play an important role due to their intrinsic merits such as high sensitivity,good accuracy,ability to distinguish the endogenous or exogenous sources of materials,and ability of in situ and in vivo analysis.This article reviews recent progress of applications of radioanalytical methods in nanotoxicology studies,with emphasis on radiolabeling methods of nanomaterials.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2011年第7期1527-1533,共7页
Progress in Chemistry
基金
国家重点基础研究发展计划(973)项目(No.2011CB933400)
国家自然科学基金项目(No.10875136
10905062
11005118)资助
关键词
放射分析
纳米毒理学
纳米材料
radioanalytical methods
nanotoxicology
nanomaterials
