摘要
目的:探讨刺五加胶囊的成型工艺。方法:考察不同辅料对主药吸湿性的影响;以颗粒的合格率作为指标,筛选最佳制粒成型工艺条件,并考察颗粒的临界相对湿度,休止角及堆密度。结果:主药与可溶性淀粉、微晶纤维素按40∶45∶15的比例混匀,加入70%乙醇制软材,20目筛制粒,所得颗粒的休止角为33.5°,堆密度为0.38 g.mL-1,临界相对湿度为66%。结论:该成型工艺合理、可行,为大生产提供了科学依据。
Objective：To investigate the formulation procedure of Acanthopanax senticosus capsule.Method： The influence of different excipients on the hygroscopicity of the main medicines was investigated by screening the best processing technology conditions and inspecting the critical relative humidity,angle of repose,and bulk density.Result： The main medicines and soluble starch,microcrystalline cellulose were mixed by a ratio of 40∶45∶15,70% ethanol was added to make materials soft,20 mesh sieve granulation.The angle of repose of the particles was 33.5°,the bulk density 0.38 g·mL-1,the critical relative humidity 66%.Conclusion： The molding technology is reasonable and can provide reliable basis for large-scale production.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第14期4-6,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
重大新药创制项目(2009ZX09103)
关键词
刺五加胶囊
成型工艺
临界相对湿度
休止角
堆密度
帕金森病
Acanthopanax senticosus capsule
formation technology
critical relative humidity
angle of repose
bulk density
parkinson＇s disease
