摘要
目的 探讨地塞米松（Ｄｅｘ）在急性肝损伤中的作用及机制。方法 用Ｄ－ 半乳糖胺（Ｄ－ ＧａｌＮ）加内毒素脂多糖（ＬＰＳ） 制成大鼠急性肝损伤模型，并用Ｄｅｘ 预处理。结果 Ｄｅｘ 组肝损伤明显减轻，伴有血中一氧化氮（ＮＯ） 含量、肝组织中ＭＤＡ及铁含量降低，ＳＯＤ活性及锌含量增高。结论 Ｄｅｘ 对此种肝损伤有保护作用，这种保护作用可能与其抑制ＮＯ 过量产生，抑制脂质过氧化反应，增加组织抗氧化活性有关。
Objective To explore the effect of dexamethasone (Dex) on the acute liver injury induced by D-Galactosamine (D-GalN)/lipopolysaccharide(LPS) and the mechanism of its action.Methods Rats were injected intraperitoneally with D-GalN 600 mg/kg plus LPS 0 1 mg/kg and those in the Dex group were pretreated by Dex 4 mg/kg.Results The results showed that serum ALT (375±342 U/L),AST(683±367),TBil(3 21±2 83) in Dex group were significantly lower than that in model group (ALT,2352±698;AST,3548±285;TBil,20 71±5 92 P <0 01).Besides,Dex reduced the elevation of NO in serum and MDA,iron in liver tissues,while SOD and zinc changes were in opposition to MDA.Conclusion The results suggested that Dex has protective effects on the acute liver injury.This function may be correlatted with that Dex can inhibite lipid peroxide and increase the tissues antioxidation. [
出处
《中国急救医学》
CAS
CSCD
北大核心
1999年第11期646-647,共2页
Chinese Journal of Critical Care Medicine
关键词
急性
肝损伤
地塞米松
一氧化氮
脂质过氧化
Acute liver injury
Dexamethasone
Nitric oxide
Lipid peroxidation
