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整合素α6、β-微精浆蛋白基因和染色体8q24区与前列腺癌的关联研究 被引量:5

A correlation study between ITGA6 gene, chromosome 8q24, MSMB genes and prostate cancer
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摘要 目的探讨整合素α6(ITGA6)基因(rsl2621278,G)、染色体8q24区(rs10086908,T)和β-微精浆蛋白(MSMB)基因(rs10993994,T)与北京市居民中前列腺癌(PCa)的关联,了解PCa患者基因型和表型的关系。方法收集112例PCa患者临床、遗传、膳食习惯、嗜好等表型,对PCa患者和91名正常对照者的ITGA6基因(rs12621278,G)、染色体8q24区(rs10086908,T)和MSMB基因(rs10993994,T)进行比较,并进行病例组的基因型-表型分析。结果2组间相比,MSMB基因rs10993994,T风险等位基因频率差异有统计学意义(病例组56.4%,对照组46.2%;P=0.001,OR:1.97,95%CI为1.28~3.04)。8q24区的rs10086908,T(病例组83.5%,对照组79.2%)和ITGA6基因的rs12621278,G(病例组27.2%,对照组27.0%)组间差异无统计学意义(P〉0.05)。数量性状分析发现ITGA6风险基因型(G/G)的患者病程为(1.40±0.55)年,显著短于A/G型的(4.38±3.10)年和A/A型的(2.37±1.84)年(P=0.003)。结论MSMB基因变异和PCa易感性之间存在相关件.根示MSMB甚丙可能与PCa右芒麟. Objective To explore the correlation between ITGA6 gene (rs12621278, G) , MSMB gene (rs10993994, T), chromosome 8q24 (rs10086908, T) and prostate cancer (PCa) in Beijing residents, and to explore the correlation between genotype and phenotype in PCa patients. Methods PCa patient phenotypes were collected including clinical, genetic, dietary habits, hobbies and blood samples. ITGA6 gene (rs12621278, G), chromosome 8q24 (rs10086908, T) and MSMB gene (rs10993994, T) compared the allele distribution between 112 PCa and 91 healthy control age matched patients. The genotype and phenotype analysis was conducted in the 2 groups. Results Between the case and control groups, only rs10993994, T of MSMB gene ( case 56.4% , control 46.2% ) was significantly different (P = 0. 001 ; 0R=1.97, 95%CI:1.28 -3.04). The rs10086908, T of 8q24 (case 83.5%, control 79.2%) and rs12621278, G of ITGA6 gene ( case 27.2% , control 27.0% ) were not significantly associated with PCa in the study sample ( P 〉 0.05 ). Quantitative trait analysis showed that the disease duration of ITGA6 risk genotypes ( G/G, 1.40 ± 0.55 years) in PCa patients was significantly shorter ( P = 0. 003 ) than the other geno- type carriers (A/G, 4.38 ± 3.10 years; A/A, 2.37± 1.84 years). Conclusion The genetic variation in MSMB is possibly associated with PCa susceptibility, suggesting that MSMB genes might be associated with PCa in a Chinese population.
出处 《中华泌尿外科杂志》 CAS CSCD 北大核心 2011年第7期471-476,共6页 Chinese Journal of Urology
基金 卫生部部属医院临床学科重点项目(10120101) 北京医院重大基金(BJ-2010-30)
关键词 ITGA6基因 染色体8q24 MSMB基因 前列腺肿瘤 关联 ITGA6 gene Chromosome 8q24 MSMB gene Prostatic neoplasms Association
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