摘要
目的观察液氮联合曲安奈德注射液治疗斑秃的临床疗效。方法随机将120例患者分为试验组(n=60例)和对照组(n=60例),试验组将棉签浸蘸液氮后涂抹于皮损区,再于皮损内注射曲安奈德注射液;对照组则在皮损内直接注射曲安奈德注射液;两组均每周治疗1次,4次为1个疗程。治疗后每2个月复查1次,随访6个月,并记录治疗过程中的不良反应和复发情况。结果试验组痊愈率、有效率及、总有效率明显高于对照组,差异有统计学意义(P<0.05或P<0.01);治疗后比较,治疗组的血管内皮素水平较对照组下降明显,具有差异具有统计学意义(P<0.01),治疗组的白介素-2水平较对照组明显升高,两组相比差异具有统计学意义(P<0.01)。结论液氮联合曲安奈德注射液治疗斑秃疗效肯定,无明显不良反应。
Objective To observe and analyze the clinical effect of patients with alopecia areata by combining liquid nitrogen with Triamcinolone acetonaide injection.Methods A total of 120 patients were randomly divided into treatment group（60 cases） and control group（60 cases）.In the treatment group we firstly dipped cotton swab into liquid nitrogen several seconds and then the lesion areas,then injected Triamcinolone acetonaide into the lesion areas.In the control group we injected Triamcinolone acetonaide into the lesion areas directly.The schedule was done once per week,4 times for a course.All patients were reexamined once every 2 months,followed up for 6 months.Adverse events during treatment and relapse cases were recoded.Results The indicators of treatment group such as cure rate,efficiency and total efficiency were significantly higher than the control group,which had statistically significant difference（P0.05 or P0.01）.After treatment the endothelin levels of the treatment group significantly decreased compared with the control group,which had statistically significant difference（P0.01）,the IL-2 levels of the treatment group were markedly increased,which had statistically significant difference（P0.01）.Conclusion The treatment of alopecia areata by combining liquid nitrogen with Triamcinolone acetonaide is effective and has no adverse effects.
出处
《实用临床医药杂志》
CAS
2011年第11期65-67,共3页
Journal of Clinical Medicine in Practice
关键词
斑秃
液氮
曲安奈德
alopecia areata
liquid nitrogen
Triamcinolone acetonaide
