摘要
为了研究六茜素注射液的安全性,进行了六茜素注射液的亚慢性毒性试验。试验每天给大白鼠灌服六茜素注射液80、1603、20 mg/kg,对各组大白鼠的体重变化、脏器系数、血液生理生化指标及心脏、肝脏、脾脏、肾脏、胸腺等脏器病理变化进行了测定和分析。结果表明,试验组大白鼠的各脏器无明显肉眼可见剖检病变;试验组大白鼠的各脏器系数与对照组差异不显著(P>0.05);320 mg/kg剂量组大白鼠的肝脏和肾脏器官出现轻微的病理变化。结果说明,六茜素注射液毒性低,可以安全用于动物。
In order to study security of the pyroline injection,the subchronic toxicity was investigated.Experimental mouse were fed daily to the pyroline injection 80,160,320 mg/kg,mouse in each group weight change,organ coefficient,blood biochemical indices and check the heart,liver,spleen,kidney,thymus and other organs,pathological changes were measured and analyzed.The results showed that,there was no pathological change in viscera,after mice of the test groups were killed.Organ coefficients of mice were no significant difference（P〉0.05） between the control and test groups.The liver and kidney tissue of mice in test group 320 mg/kg changed slightly.Results showed that the pyroline injection of low toxicity can be safely used for animals.
出处
《中国畜牧兽医》
CAS
北大核心
2011年第7期209-211,共3页
China Animal Husbandry & Veterinary Medicine
基金
国家"十一五"科技支撑计划项目(2006BAD04A05-05)
关键词
六茜素注射液
亚慢性毒性试验
体重变化
脏器系数
病理切片
the pyroline injection
subchronic toxicity test
weight change
organ coefficient
tissue slice
