摘要
目的:制备布洛芬精氨酸盐注射液并对其进行稳定性考察。方法:优化处方工艺后对布洛芬精氨酸盐注射液进行稳定性考察。采用反相高效液相色谱法测定布洛芬含量。结果:影响因素试验、加速试验及长期试验结果表明,布洛芬精氨酸盐注射液稳定。结论:布洛芬精氨酸盐注射液处方设计合理,工艺可行,质量稳定。
Objective：To develop an injectable formulation of ibuprofen arginine and to test its stability.Methods：The stability of ibuprofen arginine injection was carried out after selecting the optimal prescription.Ibuprofen in the injection was assayed using a reverse phase high performance liquid chromatography（RP-HPLC） method.Results：Ibuprofen arginine injection was stable,which was confirmed by stress,accelerated and long-term stability studies.Conclusion：The formulation of ibuprofen arginine injection is stable and suitable for industrial production.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2011年第13期1247-1250,共4页
Chinese Journal of New Drugs
