摘要
目的 研究丹参对缺氧缺血性脑病（ＨＩＥ）的疗效。 方法 在支持及对症治疗的基础上加用丹参注射液２ ｍ ｌ／（ｋｇ－ １ ·ｄ－ １ ），对３２例ＨＩＥ患儿进行治疗，疗程平均１２．７±３．３天，并与３０例不用丹参组进行对照。观察两组患儿在治疗前后新生儿神经行为评分（ＮＢＮＡ）；以Ｔｒａｎｓ－ｌｉｎｋ ＴＭ ９ ０００经颅多谱勒脑血流分析仪测量两组患儿双侧大脑中动脉血流收缩峰速度（Ｖｓ）、舒张末速度（Ｖｄ）、平均速度（Ｖｍ ）及阻力指数（ＲＩ），计算两侧的流速非对称指数（ＡＩ）；并采用中科院心理所ＣＤＣＣ进行远期智测随访。 结果 治疗组ＮＢＮＡ≥３５分：第７、１４天分别为１７、２８例，对照组８、１９例（χ２＝ ４．５０４，Ｐ＜０．０５）。脑血流动力学检查示治疗组及对照组第１天大脑中动脉平均血流速度（ｃｍ ／ｓ）分别为２１．２±４．５、１６．１±５．１，阻力指数分别为０．７１±０．１１、０．８２±０．２１，（Ｐ＜ ０．０５）。第３、５天对照组先后６例出现脑血管痉挛，治疗组无一例发生；治疗组流速非对称指数（ＡＩ）也明显低于对照组（ｔ＝ ２．６０２、２．２２６，Ｐ＜０．０５）。经６～１４个月随访，治疗组及对照组后遗症分别为２例、８?
Objective To study the therapeutic effect of Dan Sen on hypoxic ischemic encephalopathy of neonates. Methods 62 cases of hypoxic ischemic encephalopathy newborn infants with supportive and symptomatic therapy were divided into two groups:32 cases(Group A)were treated with Dan Sen (2 ml/kg·d) and 30 cases (Group B) as the control without administration of Dan Sen. All babies were studied about Neonatal Behavioral. Neurological. Assessment (NBNA) and some cerebral hemolynamic items at early age, and all were followed up. Results (1)The percentage of score≥35' at 7 and 14 day in A and B group were 53.1%, 87.5% and 26.7%, 63,3% . χ 2=4.504 P <0.05.(2)The exami nation of TCD showed that the Vm and the RI of MCA in group A and B in the first day were (21.2±4.5)cm/s,(16 61±5 1)cm/s,0 71±0 11,0.82±0 21 P < 0.02. The AI of group A and B were 3.07±0.58, 3.47±0.61 (3rd day), 5.11± 0.66, 5.50± 0.74 (5th day), P <0.05. (3)The sequelae rates in group A and group B fellowed up for 6 to 14 months. were 6.3% and 36.6%. χ 2=4.771 P <0.05 Conclusion Dan Sen had more therapeutic on hypoxic ischemic encephalopathy of newborn infant.
出处
《中华围产医学杂志》
CAS
1999年第4期222-224,共3页
Chinese Journal of Perinatal Medicine
基金
国家医学攻关项目<围产期缺氧缺血性脑损伤早期诊断及防治研究>基金
关键词
丹参
新生儿
缺氧缺血性脑病
注射液
Cerebral anoxia Cerebral-ischemia Infant,newborn Salvia miltiorrhiza
