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5-Fu及亚叶酸钙联合奥沙利铂治疗晚期胃癌临床观察 被引量:3

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摘要 目的观察5-氟尿嘧啶(5-Fu)、亚叶酸钙(CF)联合奥沙利铂(OXA)方案治疗晚期胃癌的临床疗效及毒副反应。方法第1天采用OXA 85mg/m2,静脉滴注2h;第1天和第2天CF 200mg/m2,静脉滴注2h;第1天和第2天5-Fu 400mg/m2,静脉推注,然后600mg/m2持续静脉滴注22h。每2周重复1次,28d为1个周期,至少治疗2个周期。按RECIST实体瘤疗效评定标准评价疗效及毒副反应。结果全组38例患者,近期客观有效率57.9%(22/38)。临床获益率76.3%(29/38)。中位进展时间7.6个月,中位生存时间10.9个月。毒副反应轻,无化疗相关性死亡。结论 5-Fu及CF联合OXA治疗晚期胃癌毒副反应低,是治疗进展期胃癌的较好方案之一。
作者 明汇
出处 《白求恩军医学院学报》 2011年第4期285-286,共2页 Journal of Bethune Military Medical College
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